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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.229-235

2001

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Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Antimicrobial Agents and Chemotherapy, 2000-12, Vol.44 (12), p.3465-3472

2000

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Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Antimicrobial agents and chemotherapy, 2016-08, Vol.60 (8), p.4659-4669

2016

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Manadomanzamines A and B: A Novel Alkaloid Ring System with Potent Activity against Mycobacteria and HIV-1

Journal of the American Chemical Society, 2003-11, Vol.125 (44), p.13382-13386

2003

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Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.158-165

2001

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Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

Antimicrobial Agents and Chemotherapy, 2000-06, Vol.44 (6), p.1757-1760

2000

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Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1994-2001

2005

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Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Antimicrobial Agents and Chemotherapy, 1998-11, Vol.42 (11), p.2804-2809

1998

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Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Molecular pharmacology, 1991-02, Vol.39 (2), p.258-266

1991

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Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Antiviral therapy, 2011-01, Vol.16 (7), p.1123-1130

2011

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Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Antiviral research, 2002-07, Vol.55 (1), p.141-150

2002

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Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Antiviral research, 2004-04, Vol.62 (1), p.57-64

2004

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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Antimicrobial Agents and Chemotherapy, 1992-12, Vol.36 (12), p.2686-2692

1992

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Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Antimicrobial Agents and Chemotherapy, 1990-06, Vol.34 (6), p.1061-1067

1990

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Cell-Based and Animal Models for Hepatitis B and C Viruses

Antiviral chemistry & chemotherapy, 1999-05, Vol.10 (3), p.99-114

1999

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Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Antimicrobial Agents and Chemotherapy, 1999-04, Vol.43 (4), p.920-924

1999

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Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys

Antimicrobial Agents and Chemotherapy, 1991-05, Vol.35 (5), p.801-807

1991

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Probing the Mechanistic Consequences of 5-Fluorine Substitution on Cytidine Nucleotide Analogue Incorporation by HIV-1 Reverse Transcriptase

Antiviral Chemistry and Chemotherapy, 2003-06, Vol.14 (3), p.115-125

2003

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Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes

Antimicrobial Agents and Chemotherapy, 1997-11, Vol.41 (11), p.2502-2510

1997

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Interactions of enantiomers of 2', 3'-didehydro-2', 3'-dideoxyfluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

Antiviral research, 2002-12, Vol.56 (3), p.189-205

2002

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Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol

Biochemical pharmacology, 1993-07, Vol.46 (2), p.251-255

1993

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Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions

Antimicrobial Agents and Chemotherapy, 1994-02, Vol.38 (2), p.268-274

1994

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Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks

Antiviral research, 2000, Vol.45 (1), p.19-32

2000

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Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol

Antimicrobial Agents and Chemotherapy, 1989-12, Vol.33 (12), p.2149-2151

1989

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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094

Manadomanzamines A and B: A Novel Alkaloid Ring System with Potent Activity against Mycobacteria and HIV-1

Mechanism of Action of 1-β-d-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-β-d-Dioxolane Guanosine

Effect of Oral Administration of Emtricitabine on Woodchuck Hepatitis Virus Replication in Chronically Infected Woodchucks

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Pharmacodynamics of (−)-β-2′,3′-Dideoxy-3′-Thiacytidine in Chronically Virus-Infected Woodchucks Compared to Its Pharmacodynamics in Humans

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans

Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine

Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of d- and l-D4FC-TP

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1

Cell-Based and Animal Models for Hepatitis B and C Viruses

Pharmacokinetics of β-l-2′,3′-Dideoxy-5-Fluorocytidine in Rhesus Monkeys

Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys

Probing the Mechanistic Consequences of 5-Fluorine Substitution on Cytidine Nucleotide Analogue Incorporation by HIV-1 Reverse Transcriptase

Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes

Interactions of enantiomers of 2', 3'-didehydro-2', 3'-dideoxyfluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase

Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol

Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions

Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication in chronic WHV carrier woodchucks

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol

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