UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 26

Sortiert nach

Advances in the integration of drug metabolism into the lead optimization paradigm

Mini reviews in medicinal chemistry, 2009-06, Vol.9 (6), p.703

Korfmacher, Walter A

2009

Link zum Volltext

Verfügbarkeit prüfen

The role of hyphenated chromatography-mass spectrometry techniques in exploratory drug metabolism and pharmacokinetics

Current pharmaceutical design, 2009-07, Vol.15 (19), p.2251

2009

Link zum Volltext

Verfügbarkeit prüfen

High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometry for the detection of 17alpha-ethinylestradiol in hepatocytes

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-07, Vol.870 (2), p.186-191

2008

Link zum Volltext

Verfügbarkeit prüfen

Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples

Rapid communications in mass spectrometry, 2006-01, Vol.20 (14), p.2215-2221

2006

Link zum Volltext

Verfügbarkeit prüfen

Direct Plasma Analysis of Drug Compounds Using Monolithic Column Liquid Chromatography and Tandem Mass Spectrometry

Analytical chemistry (Washington), 2003-04, Vol.75 (8), p.1812-1818

2003

Link zum Volltext

Verfügbarkeit prüfen

The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a thrombin receptor antagonist for development

Current pharmaceutical design, 2009-07, Vol.15 (19), p.2262

2009

Link zum Volltext

Verfügbarkeit prüfen

Principles and applications of LC-MS in new drug discovery

Drug discovery today, 2005-10, Vol.10 (20), p.1357-1367

Korfmacher, Walter A

2005

Link zum Volltext

Verfügbarkeit prüfen

Rapid LC/MS/MS Method Development for Drug Discovery

Analytical chemistry (Washington), 2005-10, Vol.77 (19), p.389 A-394 A

2005

Link zum Volltext

Verfügbarkeit prüfen

Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (21), p.6001-6003

2013

Link zum Volltext

Verfügbarkeit prüfen

HRMS in DMPK

Bioanalysis, 2016-08, Vol.8 (16), p.1635-1637

2016

Link zum Volltext

Verfügbarkeit prüfen

A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples

Rapid communications in mass spectrometry, 2003-01, Vol.17 (14), p.1573-1578

2003

Link zum Volltext

Verfügbarkeit prüfen

The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena

Bioanalysis, 2012-03, Vol.4 (5), p.467-469

2012

Link zum Volltext

Verfügbarkeit prüfen

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2519-2523

2009

Link zum Volltext

Verfügbarkeit prüfen

Direct cocktail analysis of drug discovery compounds in pooled plasma samples using liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002-02, Vol.767 (2), p.353-362

2002

Link zum Volltext

Verfügbarkeit prüfen

Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery

Journal of medicinal chemistry, 2022-04, Vol.65 (7), p.5575-5592

2022

Link zum Volltext

Verfügbarkeit prüfen

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.989-994

2006

Link zum Volltext

Verfügbarkeit prüfen

Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Analyst (London), 2001-12, Vol.126 (12), p.2139-2143

2001

Link zum Volltext

Verfügbarkeit prüfen

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Rapid communications in mass spectrometry, 1999-05, Vol.13 (10), p.901-907

1999

Link zum Volltext

Verfügbarkeit prüfen

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

Link zum Volltext

Verfügbarkeit prüfen

Lead optimization strategies as part of a drug metabolism environment

Current opinion in drug discovery & development, 2003-07, Vol.6 (4), p.481

Korfmacher, Walter A

2003

Link zum Volltext

Verfügbarkeit prüfen

Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2359-2364

2010

Link zum Volltext

Verfügbarkeit prüfen

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Rapid communications in mass spectrometry, 2000-08, Vol.14 (15), p.1384-1390

2000

Link zum Volltext

Verfügbarkeit prüfen

Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1037

2003

Link zum Volltext

Verfügbarkeit prüfen

Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its pharmacokinetic-pharmacodynamic relationship in a feline model of nasal congestion

Drug metabolism letters, 2010-04, Vol.4 (2), p.56

2010

Link zum Volltext

Verfügbarkeit prüfen

Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A)

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.256

2011

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 26

Suche als RSS-Feed

Aktive Filter

Zeitschrift / SerieJournal Of Mass Spectrometry.

ThemaHumans

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(25)
Mit Volltextzugriff
(17)

Publikationsform

Artikel
(26)

Sprache

Englisch
(26)
Japanisch
(3)

Erscheinungsjahr

n.n

Menü

Weitere Dienste

Einstellungen

Advances in the integration of drug metabolism into the lead optimization paradigm

The role of hyphenated chromatography-mass spectrometry techniques in exploratory drug metabolism and pharmacokinetics

High-performance liquid chromatography-atmospheric pressure photoionization/tandem mass spectrometry for the detection of 17alpha-ethinylestradiol in hepatocytes

Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples

Direct Plasma Analysis of Drug Compounds Using Monolithic Column Liquid Chromatography and Tandem Mass Spectrometry

The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a thrombin receptor antagonist for development

Principles and applications of LC-MS in new drug discovery

Rapid LC/MS/MS Method Development for Drug Discovery

Synthesis and SAR studies of benzimidazolone derivatives as histamine H3-receptor antagonists

HRMS in DMPK

A fully automated nanoelectrospray tandem mass spectrometric method for analysis of Caco-2 samples

The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety

Direct cocktail analysis of drug discovery compounds in pooled plasma samples using liquid chromatography–tandem mass spectrometry

Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists

Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Lead optimization strategies as part of a drug metabolism environment

Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)

Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its pharmacokinetic-pharmacodynamic relationship in a feline model of nasal congestion

Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A)

Aktive Filter

Suchergebnisse filtern