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What keeps us ticking: a funny current, a calcium clock, or both?

Journal of molecular and cellular cardiology, 2009-08, Vol.47 (2), p.157-170

2009

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So! What's aging? Is cardiovascular aging a disease?

Journal of molecular and cellular cardiology, 2015-06, Vol.83, p.1-13

Lakatta, Edward G

2015

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Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node

Cell calcium (Edinburgh), 2018-09, Vol.74, p.168-179

2018

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Effects of calorie restriction on cardioprotection and cardiovascular health

Journal of molecular and cellular cardiology, 2011-08, Vol.51 (2), p.263-271

2011

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New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

Journal of molecular and cellular cardiology, 2013-09, Vol.62, p.80-89

2013

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Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study

Atherosclerosis, 2011-04, Vol.215 (2), p.459-464

2011

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Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

Journal of molecular and cellular cardiology, 2014-12, Vol.77, p.1-10

2014

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Prevalence, Clinical Correlates, and Functional Impact of Subaortic Ventricular Septal Bulge (from the Baltimore Longitudinal Study of Aging)

The American journal of cardiology, 2014-09, Vol.114 (5), p.796-802

2014

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Proinflammation: the key to arterial aging

Trends in endocrinology and metabolism, 2014-02, Vol.25 (2), p.72-79

2014

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β2 AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation

Journal of molecular and cellular cardiology, 2011-10, Vol.51 (4), p.529-533

2011

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Contribution of Central Adiposity to Left Ventricular Diastolic Function (from the Baltimore Longitudinal Study of Aging)

The American journal of cardiology, 2012-04, Vol.109 (8), p.1171-1178

2012

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Perspectives on mammalian cardiovascular aging: humans to molecules

Comparative Biochemistry and Physiology, Part A, 2002-08, Vol.132 (4), p.699-721

2002

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Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

Journal of molecular and cellular cardiology, 2014-01, Vol.66, p.106-115

2014

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RGS2 overexpression or Gi inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

Journal of molecular and cellular cardiology, 2012-11, Vol.53 (5), p.687-694

2012

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Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling

Journal of molecular and cellular cardiology, 2011-01, Vol.50 (1), p.66-76

2011

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Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Heart, lung & circulation, 2007-10, Vol.16 (5), p.335-348

2007

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Superoxide Flashes in Single Mitochondria

Cell, 2008-07, Vol.134 (2), p.279-290

2008

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Aging, MicroRNAs, and Heart Failure

Current problems in cardiology, 2020-12, Vol.45 (12), p.100406-100406, Article 100406

2020

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Involvement of NADPH oxidase in age-associated cardiac remodeling

Journal of molecular and cellular cardiology, 2010-04, Vol.48 (4), p.765-772

2010

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Associations of large artery structure and function with adiposity: Effects of age, gender, and hypertension. The SardiNIA Study

Atherosclerosis, 2012-03, Vol.221 (1), p.189-197

2012

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Bringing prevention in geriatrics: Evidences from cardiovascular medicine supporting the new challenge

Experimental gerontology, 2013-01, Vol.48 (1), p.64-68

2013

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Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca2+ clock generate robust, flexible, and energy-efficient cardiac pacemaking

Journal of molecular and cellular cardiology, 2013-06, Vol.59, p.181-195

2013

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Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells

Journal of molecular and cellular cardiology, 2015-09, Vol.86, p.168-178

2015

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Chronic Alternate-Day Fasting Results in Reduced Diastolic Compliance and Diminished Systolic Reserve in Rats

Journal of cardiac failure, 2010-10, Vol.16 (10), p.843-853

2010

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Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Cytokine (Philadelphia, Pa.), 2018-11, Vol.111, p.189-193

2018

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What keeps us ticking: a funny current, a calcium clock, or both?

So! What's aging? Is cardiovascular aging a disease?

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node

Effects of calorie restriction on cardioprotection and cardiovascular health

New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling

Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study

Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells

Prevalence, Clinical Correlates, and Functional Impact of Subaortic Ventricular Septal Bulge (from the Baltimore Longitudinal Study of Aging)

Proinflammation: the key to arterial aging

β2 AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation

Contribution of Central Adiposity to Left Ventricular Diastolic Function (from the Baltimore Longitudinal Study of Aging)

Perspectives on mammalian cardiovascular aging: humans to molecules

Sarcoplasmic reticulum Ca2+ cycling protein phosphorylation in a physiologic Ca2+ milieu unleashes a high-power, rhythmic Ca2+ clock in ventricular myocytes: Relevance to arrhythmias and bio-pacemaker design

RGS2 overexpression or Gi inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling

Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Superoxide Flashes in Single Mitochondria

Aging, MicroRNAs, and Heart Failure

Involvement of NADPH oxidase in age-associated cardiac remodeling

Associations of large artery structure and function with adiposity: Effects of age, gender, and hypertension. The SardiNIA Study

Bringing prevention in geriatrics: Evidences from cardiovascular medicine supporting the new challenge

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca2+ clock generate robust, flexible, and energy-efficient cardiac pacemaking

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Kinetics of PKA activation in heart pacemaker cells

Chronic Alternate-Day Fasting Results in Reduced Diastolic Compliance and Diminished Systolic Reserve in Rats

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

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