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Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Biophysical journal, 2018-03, Vol.114 (5), p.1176-1189

2018

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Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Frontiers in physiology, 2022-04, Vol.13, p.845634-845634

2022

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Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling

International journal of molecular sciences, 2021-08, Vol.22 (17), p.9343

2021

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Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats

International journal of molecular sciences, 2018-10, Vol.19 (10), p.3168

2018

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Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

Arteriosclerosis, thrombosis, and vascular biology, 2006-07, Vol.26 (7), p.1503-1509

2006

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Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons

Heart failure reviews, 2002-01, Vol.7 (1), p.29-49

Lakatta, Edward G

2002

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β2 AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation

Journal of molecular and cellular cardiology, 2011-10, Vol.51 (4), p.529-533

2011

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Gi-Biased β2AR Signaling Links GRK2 Upregulation to Heart Failure

Circulation research, 2012-01, Vol.110 (2), p.265-274

2012

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RGS2 overexpression or Gi inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

Journal of molecular and cellular cardiology, 2012-11, Vol.53 (5), p.687-694

2012

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Sinoatrial node cells and tissue operate via stochastic resonance

Biophysical journal, 2023-02, Vol.122 (3), p.382a-382a

2023

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Super-resolved SIM imaging revealed hierarchical organization of the ryanodine receptor network in 3 dimensions in rabbit sinoatrial node cells

Biophysical journal, 2023-02, Vol.122 (3), p.236a-236a

2023

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Synchronization of pacemaker cell firing underlies autonomic modulation of beating intervals and their variability in a numerical model of heterogeneous SA node tissue

Biophysical journal, 2023-02, Vol.122 (3), p.236a-236a

2023

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Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Heart, lung & circulation, 2007-10, Vol.16 (5), p.335-348

2007

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Prevalence and Prognostic Significance of Exercise-Induced Nonsustained Ventricular Tachycardia in Asymptomatic Volunteers

Journal of the American College of Cardiology, 2013-08, Vol.62 (7), p.595-600

2013

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Beneficial effects of AT1 antagonists treatment, losartan, on cardiovascular and cognitive function on aged male Dahl salt sensitive rats

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression

Biophysical journal, 2023-02, Vol.122 (3), p.479a-480a

2023

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Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node

Biophysical journal, 2023-02, Vol.122 (3), p.233a-233a

2023

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Longitudinal decline in peak V̇o 2 with aging in a healthy population is associated with a reduction in peripheral oxygen utilization but not in cardiac output

American journal of physiology. Heart and circulatory physiology, 2024-08, Vol.327 (2), p.H509-H517

2024

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Dementia associated with chronic kidney disease is accompanied by increase in plasma amyloid beta and cardiovascular dysfunction

Alzheimer's & dementia, 2021-12, Vol.17, p.e056553-n/a

2021

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A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8

Biophysical journal, 2023-02, Vol.122 (3), p.537a-537a

2023

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Bioactive Steroid Marinobufagenin in a Mouse Model of Early‐Stage Alzheimer's Disease

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity"

American journal of physiology. Heart and circulatory physiology, 2011-06, Vol.300 (6), p.H2323-4; author reply H2325-6

2011

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Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

Journal of molecular and cellular cardiology, 2013-06, Vol.59, p.181-195

2013

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Vessel Ultrasound Sonographic Assessment of Soluble Receptor for Advanced Glycation End Products Efficacy in a Rat Balloon Injury Model

Current therapeutic research, 2014-12, Vol.76 (C), p.110-115

2014

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Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling

American journal of physiology. Heart and circulatory physiology, 2014-05, Vol.306 (10), p.H1385-H1397

2014

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Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue

Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling

Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats

Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons

β2 AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation

Gi-Biased β2AR Signaling Links GRK2 Upregulation to Heart Failure

RGS2 overexpression or Gi inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells

Sinoatrial node cells and tissue operate via stochastic resonance

Super-resolved SIM imaging revealed hierarchical organization of the ryanodine receptor network in 3 dimensions in rabbit sinoatrial node cells

Synchronization of pacemaker cell firing underlies autonomic modulation of beating intervals and their variability in a numerical model of heterogeneous SA node tissue

Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Prevalence and Prognostic Significance of Exercise-Induced Nonsustained Ventricular Tachycardia in Asymptomatic Volunteers

Beneficial effects of AT1 antagonists treatment, losartan, on cardiovascular and cognitive function on aged male Dahl salt sensitive rats

The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression

Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node

Longitudinal decline in peak V̇o 2 with aging in a healthy population is associated with a reduction in peripheral oxygen utilization but not in cardiac output

Dementia associated with chronic kidney disease is accompanied by increase in plasma amyloid beta and cardiovascular dysfunction

A remarkable adaptive paradigm of heart performance and protection emerges in response to the constitutive challenge of marked cardiac-specific overexpression of adenylyl cyclase type 8

Bioactive Steroid Marinobufagenin in a Mouse Model of Early‐Stage Alzheimer's Disease

Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity"

Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking

Vessel Ultrasound Sonographic Assessment of Soluble Receptor for Advanced Glycation End Products Efficacy in a Rat Balloon Injury Model

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling

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