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Targeting proteases: successes, failures and future prospects

Nature reviews. Drug discovery, 2006-09, Vol.5 (9), p.785-799

Turk, Boris

2006

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Cysteine cathepsins and extracellular matrix degradation

Biochimica et biophysica acta, 2014-08, Vol.1840 (8), p.2560-2570

2014

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Cysteine cathepsins: From structure, function and regulation to new frontiers

Biochimica et biophysica acta, 2012-01, Vol.1824 (1), p.68-88

2012

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Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

Cells (Basel, Switzerland), 2019-03, Vol.8 (3), p.264

2019

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Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

Matrix biology, 2019-01, Vol.75-76, p.141-159

2019

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Emerging roles of cysteine cathepsins in disease and their potential as drug targets

Current pharmaceutical design, 2007-02, Vol.13 (4), p.387-403

2007

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Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases

International journal of molecular sciences, 2021-01, Vol.22 (3), p.997

2021

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Lysosomes in programmed cell death pathways: from initiators to amplifiers

Biological chemistry, 2017-03, Vol.398 (3), p.289-301

2017

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Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment

Biochimica et biophysica acta. Molecular cell research, 2020-10, Vol.1867 (10), p.118782, Article 118782

2020

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The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

Journal of the American Chemical Society, 2019-02, Vol.141 (8), p.3507-3514

2019

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Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Chemical science (Cambridge), 2018, Vol.9 (8), p.2113-2129

2018

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Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

The Journal of biological chemistry, 2008-07, Vol.283 (27), p.19140-19150

2008

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Theranostic Applications of an Ultra-Sensitive T1 and T2 Magnetic Resonance Contrast Agent Based on Cobalt Ferrite Spinel Nanoparticles

Cancers, 2022-08, Vol.14 (16), p.4026

2022

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Lysosomal cysteine cathepsins: signaling pathways in apoptosis

Biological chemistry, 2007-06, Vol.388 (6), p.555-560

2007

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Improved Cathepsin Probes for Sensitive Molecular Imaging

Molecules (Basel, Switzerland), 2022-01, Vol.27 (3), p.842

2022

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Editorial on proteases in health and disease

Molecular aspects of medicine, 2022-12, Vol.88, p.101160-101160, Article 101160

Turk, Boris

2022

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Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

Journal of cell science, 2019-03, Vol.132 (5)

2019

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Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells

Cell communication and signaling, 2021-11, Vol.19 (1), p.108-12, Article 108

2021

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Cysteine cathepsins (proteases)—On the main stage of cancer?

Cancer Cell, 2004-05, Vol.5 (5), p.409-410

2004

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Protean proteases: at the cutting edge of lung diseases

The European respiratory journal, 2017-02, Vol.49 (2), p.1501200-1501200

2017

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Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

The Journal of biological chemistry, 2004-01, Vol.279 (5), p.3578-3587

2004

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Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells

PloS one, 2015-09, Vol.10 (9), p.e0137878

2015

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Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

The Journal of biological chemistry, 2009-08, Vol.284 (33), p.21783-21787

2009

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Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

The American journal of pathology, 2012-03, Vol.180 (3), p.973-983

2012

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A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A

Pharmaceutics, 2023-10, Vol.15 (10), p.2464

2023

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Targeting proteases: successes, failures and future prospects

Cysteine cathepsins and extracellular matrix degradation

Cysteine cathepsins: From structure, function and regulation to new frontiers

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

Emerging roles of cysteine cathepsins in disease and their potential as drug targets

Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases

Lysosomes in programmed cell death pathways: from initiators to amplifiers

Epithelial-to-mesenchymal transition as the driver of changing carcinoma and glioblastoma microenvironment

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

Theranostic Applications of an Ultra-Sensitive T1 and T2 Magnetic Resonance Contrast Agent Based on Cobalt Ferrite Spinel Nanoparticles

Lysosomal cysteine cathepsins: signaling pathways in apoptosis

Improved Cathepsin Probes for Sensitive Molecular Imaging

Editorial on proteases in health and disease

Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells

Cysteine cathepsins (proteases)—On the main stage of cancer?

Protean proteases: at the cutting edge of lung diseases

Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins

Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells

Lysosomes as “Suicide Bags” in Cell Death: Myth or Reality?

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A

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