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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Blood, 2012-03, Vol.119 (13), p.3024-3030

2012

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Prolonged activity of factor IX as a monomeric Fc fusion protein

Blood, 2010-03, Vol.115 (10), p.2057-2064

2010

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Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Blood, 2010-12, Vol.116 (26), p.5842-5848

2010

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Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release

International journal of molecular sciences, 2022-10, Vol.23 (19), p.11635

2022

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Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Molecular therapy, 2011-03, Vol.19 (3), p.442-449

2011

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Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B

Blood, 2010-06, Vol.115 (23), p.4678-4688

2010

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Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

Journal of translational medicine, 2017-05, Vol.15 (1), p.94-94, Article 94

2017

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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Nature biotechnology, 2021-01, Vol.39 (1), p.47

2021

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Blood, 2005-04, Vol.105 (8), p.3079-3086

2005

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Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Blood, 2009-04, Vol.113 (16), p.3682-3689

2009

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Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

Molecular therapy, 2010-07, Vol.18 (7), p.1318-1329

2010

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Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Blood, 2009-11, Vol.114 (20), p.4562-4565

2009

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Bad cholesterol breaking really bad

Blood, 2013-11, Vol.122 (22), p.3551-3553

Nichols, Timothy C.

2013

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Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Nature medicine, 1999-01, Vol.5 (1), p.56-63

1999

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Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2019-11, Vol.39 (11), p.2261

2019

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Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

Molecular therapy, 2017-02, Vol.25 (2), p.512-522

2017

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Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer

Oncogene, 2019-05, Vol.38 (21), p.4125-4141

2019

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Superior human hepatocyte transduction with adeno-associated virus vector serotype 7

Gene therapy, 2019-12, Vol.26 (12), p.504-514

2019

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PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets

Blood, 2003-11, Vol.102 (10), p.3658-3664

2003

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Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells

Blood, 2005-01, Vol.105 (1), p.145-152

2005

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Lack of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant AAV-2 Vector in Males

Molecular therapy, 2001-12, Vol.4 (6), p.586-592

2001

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Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A

Science translational medicine, 2024-02, Vol.16 (735), p.eadh0027

2024

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Ex Vivo Porcine Arterial and Chorioallantoic Membrane Acoustic Angiography Using Dual-Frequency Intravascular Ultrasound Probes

Ultrasound in medicine & biology, 2016-09, Vol.42 (9), p.2294-2307

2016

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Animal Models of Hemophilia and Related Bleeding Disorders

Seminars in hematology, 2013-04, Vol.50 (2), p.175-184

2013

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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Prolonged activity of factor IX as a monomeric Fc fusion protein

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide

Mechanisms of Foreign Body Response Mitigation by Nitric Oxide Release

Efficacy and Safety of Long-term Prophylaxis in Severe Hemophilia A Dogs Following Liver Gene Therapy Using AAV Vectors

Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

Successful treatment of canine hemophilia by continuous expression of canine FVIIa

Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Bad cholesterol breaking really bad

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

Coronary Artery Disease Risk-Associated Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental Atherosclerosis

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer

Superior human hepatocyte transduction with adeno-associated virus vector serotype 7

PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets

Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells

Lack of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant AAV-2 Vector in Males

Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A

Ex Vivo Porcine Arterial and Chorioallantoic Membrane Acoustic Angiography Using Dual-Frequency Intravascular Ultrasound Probes

Animal Models of Hemophilia and Related Bleeding Disorders

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