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The composition of the gut microbiota shapes the colon mucus barrier

EMBO reports, 2015-02, Vol.16 (2), p.164-177

2015

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Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

PloS one, 2014-06, Vol.9 (6), p.e100217-e100217

2014

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two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (Supplement 1), p.4659-4665

2011

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A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

Science (American Association for the Advancement of Science), 2016-06, Vol.352 (6293), p.1535-1542

2016

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inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (39), p.15064-15069

2008

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Goblet cells need some stress

The Journal of clinical investigation, 2022-09, Vol.132 (17), p.1-3

2022

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Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (15), p.5645-5650

2012

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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Immunological reviews, 2014-07, Vol.260 (1), p.8-20

2014

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Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

PloS one, 2010-08, Vol.5 (8), p.e12238

2010

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Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

The Journal of experimental medicine, 2012-07, Vol.209 (7), p.1263-1272

2012

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Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (48), p.13833-13838

2016

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Keeping Bacteria at a Distance

Science (American Association for the Advancement of Science), 2011-10, Vol.334 (6053), p.182-183

2011

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Gut microbes, 2010-01, Vol.1 (1), p.51-54

2010

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Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa

Infection and Immunity, 2013-03, Vol.81 (3), p.829-837

2013

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Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains

Molecular biotechnology, 2013-06, Vol.54 (2), p.250-256

2013

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Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2

Glycobiology (Oxford), 2012-08, Vol.22 (8), p.1128-1139

2012

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Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

Infection and Immunity, 2013-09, Vol.81 (9), p.3264-3275

2013

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Core 1- and core 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

Mucosal immunology, 2016-05, Vol.10 (1), p.91-103

2016

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Site-specific O-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by the Porphyromonas gingivalis Secreted Cysteine Protease (RgpB)<inline-graphic xlink:href="sbox.jpg"/>

The Journal of biological chemistry, 2013-04, Vol.288 (20), p.14636-14646

2013

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Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture: e85254

PloS one, 2014-01, Vol.9 (1)

2014

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New developments in goblet cell mucus secretion and function

Mucosal immunology, 2015-07, Vol.8 (4), p.712-719

2015

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The composition of the gut microbiota shapes the colon mucus barrier

Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis

two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Goblet cells need some stress

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

Keeping Bacteria at a Distance

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Helicobacter pylori Infection Impairs the Mucin Production Rate and Turnover in the Murine Gastric Mucosa

Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2

Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli

Core 1- and core 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

Site-specific O-Glycosylation on the MUC2 Mucin Protein Inhibits Cleavage by the Porphyromonas gingivalis Secreted Cysteine Protease (RgpB)<inline-graphic xlink:href="sbox.jpg"/>

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture: e85254

New developments in goblet cell mucus secretion and function

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