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Dorothy Hodgkin Lecture 2014 Understanding genes identified by genome-wide association studies for Type 2 diabetes

Diabetic medicine, 2014-12, Vol.31 (12), p.1480-1487

Rutter, G. A.

2014

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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (35), p.14872-14877

2009

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Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

Journal of endocrinology, 2005-11, Vol.187 (2), p.225-235

2005

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Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion

Diabetes (New York, N.Y.), 2000-07, Vol.49 (7), p.1149-1155

2000

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When less is more: the forbidden fruits of gene repression in the adult β-cell

Diabetes, obesity & metabolism, 2013-06, Vol.15 (6), p.503-512

2013

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Variance stabilization and normalization for one-color microarray data using a data-driven multiscale approach

Bioinformatics, 2006-10, Vol.22 (20), p.2547-2553

2006

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A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Chemical communications (Cambridge, England), 2015-04, Vol.51 (27), p.6018-6021

2015

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Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

Molecular metabolism (Germany), 2024-07, Vol.85, p.101947, Article 101947

2024

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Physical Exercise–Induced Hypoglycemia Caused by Failed Silencing of Monocarboxylate Transporter 1 in Pancreatic β Cells

American journal of human genetics, 2007-09, Vol.81 (3), p.467-474

2007

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Pancreatic β-cell imaging in humans: fiction or option?

Diabetes, obesity & metabolism, 2016-01, Vol.18 (1), p.6-15

2016

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Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion

The Journal of biological chemistry, 1993-10, Vol.268 (30), p.22385-22390

1993

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Subcellular Imaging of Intramitochondrial Ca2+ with Recombinant Targeted Aequorin: Significance for the Regulation of Pyruvate Dehydrogenase Activity

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (11), p.5489-5494

1996

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Regulation of Gene Expression by Glucose in Pancreatic β-Cells (MIN6) via Insulin Secretion and Activation of Phosphatidylinositol 3′-Kinase

The Journal of biological chemistry, 2000-11, Vol.275 (46), p.36269-36277

2000

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Regulation of Mitochondrial ATP Synthesis by Calcium: Evidence for a Long-Term Metabolic Priming

Proceedings of the National Academy of Sciences - PNAS, 1999-11, Vol.96 (24), p.13807-13812

1999

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Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection

Trends in biochemical sciences (Amsterdam. Regular ed.), 2000-05, Vol.25 (5), p.215-221

2000

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Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency

Cell death and differentiation, 2010-12, Vol.17 (12), p.1855-1866

2010

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Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes

Cardiovascular research, 1998-08, Vol.39 (2), p.423-433

1998

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Involvement of Per-Arnt-Sim (PAS) Kinase in the Stimulation of Preproinsulin and Pancreatic Duodenum Homeobox 1 Gene Expression by Glucose

Proceedings of the National Academy of Sciences - PNAS, 2004-06, Vol.101 (22), p.8319-8324

2004

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Integrating cytosolic calcium signals into mitochondrial metabolic responses

The EMBO journal, 1998-09, Vol.17 (17), p.4987-5000

1998

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Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

Biochemical journal, 2004-03, Vol.378 (Pt 3), p.769-778

2004

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Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria

The Journal of biological chemistry, 1999-05, Vol.274 (19), p.13281-13291

1999

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Role of AMP-Activated Protein Kinase in the Regulation by Glucose of Islet Beta Cell Gene Expression

Proceedings of the National Academy of Sciences - PNAS, 2000-04, Vol.97 (8), p.4023-4028

2000

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Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event

Current biology, 2000-10, Vol.10 (20), p.1307-1310

2000

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Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

Diabetes (New York, N.Y.), 2001-02, Vol.50 (2), p.361-366

2001

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Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

Biochemical journal, 2004-01, Vol.377 (Pt 1), p.149-158

2004

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Dorothy Hodgkin Lecture 2014 Understanding genes identified by genome-wide association studies for Type 2 diabetes

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

Over-expression of AMP-activated protein kinase impairs pancreatic β-cell function in vivo

Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion

When less is more: the forbidden fruits of gene repression in the adult β-cell

Variance stabilization and normalization for one-color microarray data using a data-driven multiscale approach

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

Physical Exercise–Induced Hypoglycemia Caused by Failed Silencing of Monocarboxylate Transporter 1 in Pancreatic β Cells

Pancreatic β-cell imaging in humans: fiction or option?

Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion

Subcellular Imaging of Intramitochondrial Ca2+ with Recombinant Targeted Aequorin: Significance for the Regulation of Pyruvate Dehydrogenase Activity

Regulation of Gene Expression by Glucose in Pancreatic β-Cells (MIN6) via Insulin Secretion and Activation of Phosphatidylinositol 3′-Kinase

Regulation of Mitochondrial ATP Synthesis by Calcium: Evidence for a Long-Term Metabolic Priming

Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection

Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency

Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes

Involvement of Per-Arnt-Sim (PAS) Kinase in the Stimulation of Preproinsulin and Pancreatic Duodenum Homeobox 1 Gene Expression by Glucose

Integrating cytosolic calcium signals into mitochondrial metabolic responses

Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria

Role of AMP-Activated Protein Kinase in the Regulation by Glucose of Islet Beta Cell Gene Expression

Simultaneous evanescent wave imaging of insulin vesicle membrane and cargo during a single exocytotic event

Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

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