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Some remaining challenges regarding multiple endpoints in clinical trials

Statistics in medicine, 2017-12, Vol.36 (28), p.4441-4445

Snapinn, Steven

2017

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Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

The New England journal of medicine, 2001-09, Vol.345 (12), p.861-869

2001

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A shrinkage estimator for subgroup analysis without the exchangeability assumption

Journal of biopharmaceutical statistics, 2021-11, Vol.31 (6), p.723-735

Snapinn, Steven

2021

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Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

Annals of internal medicine, 2003-12, Vol.139 (11), p.901

2003

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The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL Study

Kidney international, 2003-04, Vol.63 (4), p.1499-1507

2003

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Risk Scores for Predicting Outcomes in Patients with Type 2 Diabetes and Nephropathy: The RENAAL Study

Clinical journal of the American Society of Nephrology, 2006-07, Vol.1 (4), p.761-767

2006

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University of Pennsylvania 10th annual conference on statistical issues in clinical trials: Current issues regarding data and safety monitoring committees in clinical trials (morning panel session)

Clinical trials (London, England), 2018-08, Vol.15 (4), p.335-351

2018

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Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial

JAMA : the journal of the American Medical Association, 2004-07, Vol.292 (1), p.55

2004

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Statins for Secondary Prevention of Cardiovascular Disease: The Right Dose

Pharmacology, 2011-01, Vol.87 (1-2), p.63-69

2011

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Does Albuminuria Predict Cardiovascular Outcomes on Treatment With Losartan Versus Atenolol in Patients With Diabetes, Hypertension, and Left Ventricular Hypertrophy?: The LIFE study

Diabetes care, 2006-03, Vol.29 (3), p.595-600

2006

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Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study

Journal of hypertension, 2002-09, Vol.20 (9), p.1879-1886

2002

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Hospitalizations for New Heart Failure Among Subjects With Diabetes Mellitus in the RENAAL and LIFE Studies

The American journal of cardiology, 2005-12, Vol.96 (11), p.1530-1536

2005

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Electrocardiographic Strain Pattern and Prediction of Cardiovascular Morbidity and Mortality in Hypertensive Patients

Hypertension (Dallas, Tex. 1979), 2004-07, Vol.44 (1), p.48-54

2004

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Stroke Reduction in Hypertensive Adults With Cardiac Hypertrophy Randomized to Losartan Versus Atenolol: The Losartan Intervention For Endpoint Reduction in Hypertension Study

Hypertension (Dallas, Tex. 1979), 2005-01, Vol.45 (1), p.46-52

2005

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Treatment effect measures under nonproportional hazards

Pharmaceutical statistics : the journal of the pharmaceutical industry, 2023-01, Vol.22 (1), p.181-193

2023

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Assessment of futility in clinical trials

Pharmaceutical statistics : the journal of the pharmaceutical industry, 2006-10, Vol.5 (4), p.273-281

2006

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Proportion of treatment effect (PTE) explained by a surrogate marker

Statistics in medicine, 2003-11, Vol.22 (22), p.3449-3459

2003

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Content Validity of HIT‐6 as a Measure of Headache Impact in People With Migraine: A Narrative Review

Headache, 2020-01, Vol.60 (1), p.28-39

2020

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Sex-based short- and long-term survival in patients following complicated myocardial infarction

European heart journal, 2006-09, Vol.27 (18), p.2177-2183

2006

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On the clinical meaningfulness of a treatment's effect on a time-to-event variable

Statistics in medicine, 2011-08, Vol.30 (19), p.2341-2348

2011

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Correlation between the TIMI risk score and high-risk angiographic findings in non–ST-elevation acute coronary syndromes: Observations from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) trial

The American heart journal, 2005-05, Vol.149 (5), p.846-850

2005

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Importance of baseline distribution of proteinuria in renal outcomes trials : Lessons from the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study

Journal of the American Society of Nephrology, 2005-06, Vol.16 (6), p.1775-1780

2005

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Preservation of effect and the regulatory approval of new treatments on the basis of non-inferiority trials

Statistics in medicine, 2008-02, Vol.27 (3), p.382-391

2008

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Pulse Pressure and Effects of Losartan or Atenolol in Patients With Hypertension and Left Ventricular Hypertrophy

Hypertension (Dallas, Tex. 1979), 2005-04, Vol.45 (4), p.580-585

2005

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Analysis of bleeding complications associated with glycoprotein IIb/IIIa receptors blockade in patients with high-risk acute coronary syndromes: Insights from the PRISM-PLUS study

International journal of cardiology, 2005-04, Vol.100 (1), p.73-78

2005

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Some remaining challenges regarding multiple endpoints in clinical trials

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

A shrinkage estimator for subgroup analysis without the exchangeability assumption

Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study

The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: The RENAAL Study

Risk Scores for Predicting Outcomes in Patients with Type 2 Diabetes and Nephropathy: The RENAAL Study

University of Pennsylvania 10th annual conference on statistical issues in clinical trials: Current issues regarding data and safety monitoring committees in clinical trials (morning panel session)

Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a randomized controlled trial

Statins for Secondary Prevention of Cardiovascular Disease: The Right Dose

Does Albuminuria Predict Cardiovascular Outcomes on Treatment With Losartan Versus Atenolol in Patients With Diabetes, Hypertension, and Left Ventricular Hypertrophy?: The LIFE study

Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study

Hospitalizations for New Heart Failure Among Subjects With Diabetes Mellitus in the RENAAL and LIFE Studies

Electrocardiographic Strain Pattern and Prediction of Cardiovascular Morbidity and Mortality in Hypertensive Patients

Stroke Reduction in Hypertensive Adults With Cardiac Hypertrophy Randomized to Losartan Versus Atenolol: The Losartan Intervention For Endpoint Reduction in Hypertension Study

Treatment effect measures under nonproportional hazards

Assessment of futility in clinical trials

Proportion of treatment effect (PTE) explained by a surrogate marker

Content Validity of HIT‐6 as a Measure of Headache Impact in People With Migraine: A Narrative Review

Sex-based short- and long-term survival in patients following complicated myocardial infarction

On the clinical meaningfulness of a treatment's effect on a time-to-event variable

Correlation between the TIMI risk score and high-risk angiographic findings in non–ST-elevation acute coronary syndromes: Observations from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) trial

Importance of baseline distribution of proteinuria in renal outcomes trials : Lessons from the reduction of endpoints in NIDDM with the angiotensin II antagonist losartan (RENAAL) study

Preservation of effect and the regulatory approval of new treatments on the basis of non-inferiority trials

Pulse Pressure and Effects of Losartan or Atenolol in Patients With Hypertension and Left Ventricular Hypertrophy

Analysis of bleeding complications associated with glycoprotein IIb/IIIa receptors blockade in patients with high-risk acute coronary syndromes: Insights from the PRISM-PLUS study

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