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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Cancer discovery, 2018-05, Vol.8 (5), p.632-647

2018

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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Cancer research (Chicago, Ill.), 2018-04, Vol.78 (8), p.2096-2114

2018

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Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Journal of medicinal chemistry, 2010-06, Vol.53 (11), p.4367-4378

2010

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Progress in the discovery of polo-like kinase inhibitors

Current topics in medicinal chemistry, 2005-01, Vol.5 (2), p.181-197

2005

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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

Nature chemical biology, 2006-11, Vol.2 (11), p.608-617

2006

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Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

PloS one, 2011-09, Vol.6 (9), p.e24825

2011

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2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1662-1675

2004

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Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

Journal of biomolecular screening, 2012-04, Vol.17 (4), p.460-468

2012

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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

Bioorganic & medicinal chemistry letters, 2019-04, Vol.29 (8), p.1023-1029

2019

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The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

Cell chemical biology, 2018-09, Vol.25 (9), p.1107-1116.e4

2018

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A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

Protein expression and purification, 2017-04, Vol.132, p.75-84

2017

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A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (22), p.6509-6522

2018

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Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1933-1933

2018

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A Central Role for Biophysics in Cancer Drug Discovery - Development of Candidate Small Molecule Inhibitors in Mutant KRas

Biophysical journal, 2018-02, Vol.114 (3), p.30a-31a

2018

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Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-228-LB-228

2017

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Small molecules that bind the Mdm2 RING stabilize and activate p53

Carcinogenesis (New York), 2012-04, Vol.33 (4), p.791-798

2012

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5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

Bioorganic & medicinal chemistry, 2013-11, Vol.21 (22), p.6868-6877

2013

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Alkali Metal Ion Dependence of Inositol 1,4,5-Trisphosphate-induced Calcium Release from Rat Cerebellar Microsomes

The Journal of biological chemistry, 1995-11, Vol.270 (47), p.28097-28102

1995

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A novel small-molecule MRCK inhibitor blocks cancer cell invasion

Cell communication and signaling, 2014-10, Vol.12 (1), p.54, Article 54

2014

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The Mechanism of Inhibition of the Ca2+-ATPase by Mastoparan

The Journal of biological chemistry, 1999-05, Vol.274 (21), p.14799-14805

1999

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The Effects of Inositol 1,4,5-Trisphosphate (InsP3) Analogues on the Transient Kinetics of Ca2+ Release from Cerebellar Microsomes

The Journal of biological chemistry, 1996-12, Vol.271 (50), p.31818-31823

1996

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Kinetic Properties of Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ Release

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.7669-7675

1997

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Co-Crystal Structures of Inhibitors with MRCK[beta], a Key Regulator of Tumor Cell Invasion

PloS one, 2011-09, Vol.6 (9), p.e24825

2011

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Conductimetric Assays for the Hydrolase and Transferase Activities of Phospholipase D Enzymes

Analytical biochemistry, 1994-05, Vol.218 (2), p.370-376

1994

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Synthesis and biological activity of 2-anilino-4-(1 H-pyrrol-3-yl) pyrimidine CDK inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4237-4240

2004

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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Progress in the discovery of polo-like kinase inhibitors

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

A Central Role for Biophysics in Cancer Drug Discovery - Development of Candidate Small Molecule Inhibitors in Mutant KRas

Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery

Small molecules that bind the Mdm2 RING stabilize and activate p53

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

Alkali Metal Ion Dependence of Inositol 1,4,5-Trisphosphate-induced Calcium Release from Rat Cerebellar Microsomes

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

The Mechanism of Inhibition of the Ca2+-ATPase by Mastoparan

The Effects of Inositol 1,4,5-Trisphosphate (InsP3) Analogues on the Transient Kinetics of Ca2+ Release from Cerebellar Microsomes

Kinetic Properties of Nicotinic Acid Adenine Dinucleotide Phosphate-induced Ca2+ Release

Co-Crystal Structures of Inhibitors with MRCK[beta], a Key Regulator of Tumor Cell Invasion

Conductimetric Assays for the Hydrolase and Transferase Activities of Phospholipase D Enzymes

Synthesis and biological activity of 2-anilino-4-(1 H-pyrrol-3-yl) pyrimidine CDK inhibitors

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