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Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.84-97

2018

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Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors

Antimicrobial Agents and Chemotherapy, 2011-11, Vol.55 (11), p.5099-5106

2011

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Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (9), p.1836-1841

2015

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5-Substituted-1H-tetrazoles as carboxylic acid isosteres: Medicinal chemistry and synthetic methods

Bioorganic & medicinal chemistry, 2002-11, Vol.10 (11), p.3379-3393

HERR, R. Jason

2002

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Palladium-Catalyzed Preparation of Weinreb Amides from Boronic Acids and N-Methyl-N-methoxycarbamoyl Chloride

Journal of organic chemistry, 2010-02, Vol.75 (4), p.1251-1258

2010

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Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (12), p.4237-4246

2007

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SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2890-2893

2011

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The optimization of pyridazinone series of glucan synthase inhibitors

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5268-5271

2012

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A Three-Step Method for the Preparation of N‑Substituted 3,4-Dihydroisoquinolin-1(2H)‑ones and Heteroaryl-Fused 3,4-Dihydropyridin-2(1H)‑ones from 2‑Bromobenzoate Precursors

Journal of organic chemistry, 2023-02, Vol.88 (4), p.2589-2598

2023

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Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4896-4899

2012

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Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

Bioorganic & medicinal chemistry, 2020-11, Vol.28 (22), p.115734-115734, Article 115734

2020

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Concise Enantiospecific, Stereoselective Syntheses of (+)-Crispine A and Its (−)-Antipode

Journal of organic chemistry, 2011-03, Vol.76 (6), p.1605-1613

2011

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Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme

Bioorganic & medicinal chemistry letters, 2016-08, Vol.26 (16), p.3928-3937

2016

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Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3203-3207

2015

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Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain

Bioorganic & medicinal chemistry letters, 2014-11, Vol.24 (21), p.4958-4962

2014

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A Concise Palladium-Catalyzed Carboamination Route to (±)-Tylophorine

Journal of organic chemistry, 2009-12, Vol.74 (24), p.9554-9557

2009

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Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4110-4113

2014

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Generation of 3-Pyridyl Biaryl Systems via Palladium-Catalyzed Suzuki Cross-Couplings of Aryl Halides with 3-Pyridylboroxin

Journal of organic chemistry, 2004-03, Vol.69 (6), p.2210-2212

2004

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Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6613-6617

2009

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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.744-755

2004

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Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

Organic process research & development, 2012-04, Vol.16 (4), p.550-555

2012

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The diazo ketone approach to the isoprostanes

Chemistry and Physics of Lipids, 2004-03, Vol.128 (1), p.57-67

2004

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Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel–Crafts cyclization

Tetrahedron letters, 2013-04, Vol.54 (15), p.2018-2021

2013

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A Convenient Method for the Preparation of Primary and Symmetrical N,N′-Disubstituted Thioureas

Synthesis (Stuttgart), 2000, Vol.2000 (11), p.1569-1574

2000

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Preparation of 8-Substituted Xanthine CVT-124 Precursor by Late Stage Pyrimidine Ring Closure

Journal of organic chemistry, 2002-01, Vol.67 (1), p.188-193

2002

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Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss

Discovery of a Novel Class of Orally Active Antifungal β-1,3-d-Glucan Synthase Inhibitors

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

5-Substituted-1H-tetrazoles as carboxylic acid isosteres: Medicinal chemistry and synthetic methods

Palladium-Catalyzed Preparation of Weinreb Amides from Boronic Acids and N-Methyl-N-methoxycarbamoyl Chloride

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives

SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

The optimization of pyridazinone series of glucan synthase inhibitors

A Three-Step Method for the Preparation of N‑Substituted 3,4-Dihydroisoquinolin-1(2H)‑ones and Heteroaryl-Fused 3,4-Dihydropyridin-2(1H)‑ones from 2‑Bromobenzoate Precursors

Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

Concise Enantiospecific, Stereoselective Syntheses of (+)-Crispine A and Its (−)-Antipode

Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme

Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4

Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain

A Concise Palladium-Catalyzed Carboamination Route to (±)-Tylophorine

Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers

Generation of 3-Pyridyl Biaryl Systems via Palladium-Catalyzed Suzuki Cross-Couplings of Aryl Halides with 3-Pyridylboroxin

Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

The diazo ketone approach to the isoprostanes

Synthesis of 3-benzazepines and azepino[4,5-b]heterocyclic ring systems via intramolecular Friedel–Crafts cyclization

A Convenient Method for the Preparation of Primary and Symmetrical N,N′-Disubstituted Thioureas

Preparation of 8-Substituted Xanthine CVT-124 Precursor by Late Stage Pyrimidine Ring Closure

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