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IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion

Inflammatory bowel diseases, 2014-10, Vol.20 (10), p.1794-1801

2014

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Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease

Gastroenterology (New York, N.Y. 1943), 2017-07, Vol.153 (1), p.219-232

2017

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Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells

Cytokine (Philadelphia, Pa.), 2013-07, Vol.63 (1), p.36-42

2013

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Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

Inflammatory bowel diseases, 2011-01, Vol.17 (1), p.171-178

2011

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Distinct Methylation of IFNG in the Gut

Journal of interferon & cytokine research, 2009-07, Vol.29 (7), p.407-414

2009

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S1696 TL1A Expression Is Induced During Dendritic Cell Differentiation

Gastroenterology (New York, N.Y. 1943), 2009, Vol.136 (5), p.A-252-A-252

2009

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W1178 Unique Epigenetic Modification of IFNG in Inflammatory Bowel Disease Is Linked to Functional Expression in the Mucosa

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-649-A-649

2008

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S1174 UC Patients With High Level Antibody Responses to CD-Associated Microbial Antigens Exhibit Aberrant IFNG DNA Methylation Patterns

Gastroenterology (New York, N.Y. 1943), 2010, Vol.138 (5), p.S-196-S-197

2010

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Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression

The Journal of immunology (1950), 2004-11, Vol.173 (10), p.6241-6247

2004

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T1216 DNA Methylation Status of IFNG Correlates with pANCA Reactivity in UC Patients

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (4), p.A-508-A-509

2008

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CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells

European journal of immunology, 2003-05, Vol.33 (5), p.1152-1162

2003

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Su1856 RNASET2: A CD Severity Biomarker Related to TL1A Driven Inflammation

Gastroenterology (New York, N.Y. 1943), 2016-04, Vol.150 (4), p.S571-S571

2016

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Mo1725 TL1A Mediated Activation of Early Response Genes Regulating IFNγ Expression: A Biomarker for Targeting Anti-TL1A Therapy?

Gastroenterology (New York, N.Y. 1943), 2015-04, Vol.148 (4), p.S-695-S-695

2015

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Association of RNASET2 Gene Polymorphisms with Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.153 (1), p.219-232

2017

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Tu1926 Functional Characterization of the CD40 IBD Risk SNP rs6074022: Integrated Gwas, eQTL, and mQTL Defines IBD Patient Subgroups With Altered Pathobiology and Distinct Natural History of Disease

Gastroenterology (New York, N.Y. 1943), 2014-05, Vol.146 (5), p.S-874-S-874

2014

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Tu1859 Transactivation of the Crohn's Disease Severity Gene, TL1A, Requires the Interplay Between Multiple Activating and Repressive CIS -Regulatory Regions

Gastroenterology (New York, N.Y. 1943), 2012-05, Vol.142 (5), p.S-862-S-862

2012

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Su1747 Combined Epigenetic and mRNA Expression Profiling Defines a Crohn's Disease (CD) Patient Population With Need for Early Surgical Intervention

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-466-S-466

2013

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The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

The Journal of clinical investigation, 1995-05, Vol.95 (5), p.2111-2119

1995

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A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

The Journal of immunology (1950), 1997-12, Vol.159 (12), p.6276-6282

1997

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Activation of the CD2 Pathway in Lamina Propria T Cells Up-Regulates Functionally Active AP-1 Binding to the IL-2 Promoter, Resulting in Messenger RNA Transcription and IL-2 Secretion

The Journal of immunology (1950), 1998-05, Vol.160 (10), p.4914-4922

1998

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CD28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation

The Journal of immunology (1950), 1999-06, Vol.162 (11), p.6621-6629

1999

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CCR9–Positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease

Gastroenterology (New York, N.Y. 1943), 2001-08, Vol.121 (2), p.246-254

2001

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Distinct IFNG Methylation in a Subset of Ulcerative Colitis Patients Based upon Reactivity to Microbial Antigens

Inflammatory bowel diseases, 2011-01, Vol.17 (1), p.171-178

2011

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An IFNG SNP Within a Linkage Disequilibrium Block Associated With UC and Severity is Functionally Associated With Altered IFNG Methylation and IFN-γ Protein Secretion

Gastroenterology (New York, N.Y. 1943), 2011, Vol.140 (5), p.S-835-S-835

2011

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Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway

The Journal of immunology (1950), 1995-01, Vol.154 (2), p.664-675

1995

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IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease

Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

Distinct Methylation of IFNG in the Gut

S1696 TL1A Expression Is Induced During Dendritic Cell Differentiation

W1178 Unique Epigenetic Modification of IFNG in Inflammatory Bowel Disease Is Linked to Functional Expression in the Mucosa

S1174 UC Patients With High Level Antibody Responses to CD-Associated Microbial Antigens Exhibit Aberrant IFNG DNA Methylation Patterns

Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression

T1216 DNA Methylation Status of IFNG Correlates with pANCA Reactivity in UC Patients

CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells

Su1856 RNASET2: A CD Severity Biomarker Related to TL1A Driven Inflammation

Mo1725 TL1A Mediated Activation of Early Response Genes Regulating IFNγ Expression: A Biomarker for Targeting Anti-TL1A Therapy?

Association of RNASET2 Gene Polymorphisms with Decreased Expression and Clinical Characteristics of Severity in Crohn’s Disease

Tu1926 Functional Characterization of the CD40 IBD Risk SNP rs6074022: Integrated Gwas, eQTL, and mQTL Defines IBD Patient Subgroups With Altered Pathobiology and Distinct Natural History of Disease

Tu1859 Transactivation of the Crohn's Disease Severity Gene, TL1A, Requires the Interplay Between Multiple Activating and Repressive CIS -Regulatory Regions

Su1747 Combined Epigenetic and mRNA Expression Profiling Defines a Crohn's Disease (CD) Patient Population With Need for Early Surgical Intervention

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

Activation of the CD2 Pathway in Lamina Propria T Cells Up-Regulates Functionally Active AP-1 Binding to the IL-2 Promoter, Resulting in Messenger RNA Transcription and IL-2 Secretion

CD28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation

CCR9–Positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease

Distinct IFNG Methylation in a Subset of Ulcerative Colitis Patients Based upon Reactivity to Microbial Antigens

An IFNG SNP Within a Linkage Disequilibrium Block Associated With UC and Severity is Functionally Associated With Altered IFNG Methylation and IFN-γ Protein Secretion

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway

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