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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Nature communications, 2021-06, Vol.12 (1), p.3763-3763, Article 3763

2021

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Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Cell research, 2020-05, Vol.30 (5), p.436-445

2020

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Structural insights into the activation of GLP-1R by a small molecule agonist

Cell research, 2020-12, Vol.30 (12), p.1140-1142

2020

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A dual diffusion model enables 3D molecule generation and lead optimization based on target pockets

Nature communications, 2024-03, Vol.15 (1), p.2657-2657, Article 2657

2024

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Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types

PLoS genetics, 2024-01, Vol.20 (1), p.e1011134

2024

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Structural Basis for Apelin Control of the Human Apelin Receptor

Structure (London), 2017-06, Vol.25 (6), p.858-866.e4

2017

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Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Journal of medicinal chemistry, 2018-09, Vol.61 (18), p.8186-8201

2018

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Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Cell research, 2020-05, Vol.30 (5), p.455-455

2020

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From Ab initio Quantum Mechanics to Molecular Neurobiology: A cation-π Binding Site in the Nicotinic Receptor

Proceedings of the National Academy of Sciences - PNAS, 1998-10, Vol.95 (21), p.12088-12093

1998

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Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7371-7375

2012

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Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

Journal of organic chemistry, 2009-08, Vol.74 (16), p.5975-5982

2009

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Ruthenium-Promoted C–H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids

Organic letters, 2018-08, Vol.20 (16), p.4764-4768

2018

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Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (11), p.3607-3611

2012

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Palladium-Promoted DNA-Compatible Heck Reaction

Organic letters, 2019-02, Vol.21 (3), p.719-723

2019

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Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

Organic letters, 2018-11, Vol.20 (22), p.7186-7191

2018

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Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

Bioorganic & medicinal chemistry, 2007-10, Vol.15 (20), p.6574-6595

2007

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Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.678-687

2012

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Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6591-6594

2009

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753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N‑Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Organic process research & development, 2022-11, Vol.26 (11), p.3089-3095

2022

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Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop

Structure (London), 2024-07, Vol.32 (7), p.907-917.e7

2024

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Design and synthesis of quinolin-2(1 H)-one derivatives as potent CDK5 inhibitors

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (19), p.5384-5389

2007

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Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers

Molecular cancer therapeutics, 2024-08, p.OF1-OF14

2024

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Structural insights into ligand recognition and selectivity of somatostatin receptors

Cell research, 2022-08, Vol.32 (8), p.761-772

2022

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Fragment-Based Computational Method for Designing GPCR Ligands

Journal of chemical information and modeling, 2020-09, Vol.60 (9), p.4339-4349

2020

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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Structural insights into the activation of GLP-1R by a small molecule agonist

A dual diffusion model enables 3D molecule generation and lead optimization based on target pockets

Genome-wide analyses reveal the contribution of somatic variants to the immune landscape of multiple cancer types

Structural Basis for Apelin Control of the Human Apelin Receptor

Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

From Ab initio Quantum Mechanics to Molecular Neurobiology: A cation-π Binding Site in the Nicotinic Receptor

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

Stereoselective Synthesis of anti-N-Protected 3-Amino-1,2-epoxides by Nucleophilic Addition to N-tert-Butanesulfinyl Imine of a Glyceraldehyde Synthon

Ruthenium-Promoted C–H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids

Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer’s disease

Palladium-Promoted DNA-Compatible Heck Reaction

Inverse-Electron-Demand Diels–Alder Reactions for the Synthesis of Pyridazines on DNA

Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors

753-P: RGT-075, an Orally Efficacious Small Molecule GLP-1R Full Agonist in Cynomolgus Monkey Models

Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N‑Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop

Design and synthesis of quinolin-2(1 H)-one derivatives as potent CDK5 inhibitors

Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers

Structural insights into ligand recognition and selectivity of somatostatin receptors

Fragment-Based Computational Method for Designing GPCR Ligands

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