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Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C−O Bond Formation under Mild Conditions

Angewandte Chemie International Edition, 2016-09, Vol.55 (38), p.11625-11628

International ed. in English, 2016

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Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV‑2 3CLpro)

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.2880-2904

2022

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Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization

Organic letters, 2010-03, Vol.12 (6), p.1200-1203

2010

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Discovery of Potent 2‑Aryl-6,7-dihydro‑5H‑pyrrolo[1,2‑a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623-5642

2018

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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Journal of medicinal chemistry, 2020-01, Vol.63 (2), p.656-675

2020

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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Cell reports (Cambridge), 2019-03, Vol.26 (11), p.2916-2928.e13

2019

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361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Journal of clinical and translational science, 2023-04, Vol.7 (s1), p.107-107

2023

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Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C−O Bond Formation under Mild Conditions

Angewandte Chemie, 2016-09, Vol.128 (38), p.11797-11800

2016

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Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation

Science translational medicine, 2021-05, Vol.13 (595)

2021

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Stereoselective α‑Fluorination of N‑Acyloxazolidinones at Room Temperature within 1 h

Journal of organic chemistry, 2014-07, Vol.79 (13), p.6206-6220

2014

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WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Genes & development, 2023-02, Vol.37 (3-4), p.86-102

2023

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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623-5642

2018

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Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization

Journal of medicinal chemistry, 2022-04, Vol.65 (8), p.6287-6312

2022

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Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries

Journal of the American Chemical Society, 2017-01, Vol.139 (1), p.527-533

2017

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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11232-11259

2019

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STEM-24. WDR5 REPRESENTS A THERAPEUTICALLY EXPLOITABLE TARGET FOR CANCER STEM CELLS IN GLIOBLASTOMA

Neuro-oncology (Charlottesville, Va.), 2023-11, Vol.25 (Supplement_5), p.v38-v38

2023

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STEM-14. THE WRAD COMPLEX REPRESENTS A THERAPEUTIC TARGET FOR CANCER STEM CELLS IN GLIOBLASTOMA

Neuro-oncology (Charlottesville, Va.), 2021-11, Vol.23 (Supplement_6), p.vi23-vi24

2021

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Structure-based optimization of ML300 derived, non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)

Journal of medicinal chemistry, 2021-08, Vol.65 (4), p.2880-2904

2021

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Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Non-Covalent Stereodirecting Auxiliaries

Journal of the American Chemical Society, 2016-12, Vol.139 (1), p.527-533

2016

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Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Journal of medicinal chemistry, 2020-01, Vol.63 (2), p.656-675

2020

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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo1,2- aimidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623

2018

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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Cell reports (Cambridge), 2019-03, Vol.26 (11)

2019

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On the Internet of Things, Blockchain Technology for Supply Chain Management (IoT)

Wireless communications and mobile computing, 2022-05, Vol.2022, p.1-14

2022

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Studies towards the total synthesis of (−)-galanthamine utilizing C-H functionalization as a design concept

Alvarado, Joseph Ryan

2016

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Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C−O Bond Formation under Mild Conditions

Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV‑2 3CLpro)

Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization

Discovery of Potent 2‑Aryl-6,7-dihydro‑5H‑pyrrolo[1,2‑a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C−O Bond Formation under Mild Conditions

Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation

Stereoselective α‑Fluorination of N‑Acyloxazolidinones at Room Temperature within 1 h

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization

Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Noncovalent Stereodirecting Auxiliaries

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction

STEM-24. WDR5 REPRESENTS A THERAPEUTICALLY EXPLOITABLE TARGET FOR CANCER STEM CELLS IN GLIOBLASTOMA

STEM-14. THE WRAD COMPLEX REPRESENTS A THERAPEUTIC TARGET FOR CANCER STEM CELLS IN GLIOBLASTOMA

Structure-based optimization of ML300 derived, non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)

Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Non-Covalent Stereodirecting Auxiliaries

Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo1,2- aimidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

On the Internet of Things, Blockchain Technology for Supply Chain Management (IoT)

Studies towards the total synthesis of (−)-galanthamine utilizing C-H functionalization as a design concept

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