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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Investigational new drugs, 2014-10, Vol.32 (5), p.825-837

2014

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A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

Investigational new drugs, 2014-02, Vol.32 (1), p.178-187

2014

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Development of artemisinin compounds for cancer treatment

Investigational new drugs, 2013-02, Vol.31 (1), p.230-246

2013

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Ipilimumab associated hepatitis: imaging and clinicopathologic findings

Investigational new drugs, 2013-08, Vol.31 (4), p.1071-1077

2013

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Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

Investigational new drugs, 2013-08, Vol.31 (4), p.1087-1094

2013

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Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells

Investigational new drugs, 2014-12, Vol.32 (6), p.1053-1062

2014

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Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma

Investigational new drugs, 2014-12, Vol.32 (6), p.1246-1257

2014

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Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

Investigational new drugs, 2014-08, Vol.32 (4), p.670-681

2014

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

Investigational new drugs, 2013-08, Vol.31 (4), p.833-844

2013

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PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

Investigational new drugs, 2014-10, Vol.32 (5), p.783-794

2014

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The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer

Investigational new drugs, 2014-08, Vol.32 (4), p.577-586

2014

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A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

Investigational new drugs, 2014-06, Vol.32 (3), p.436-444

2014

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Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

Investigational new drugs, 2014-06, Vol.32 (3), p.452-464

2014

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Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation

Investigational new drugs, 2014-08, Vol.32 (4), p.604-617

2014

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Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells

Investigational new drugs, 2014-12, Vol.32 (6), p.1096-1104

2014

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Kidney injuries related to ipilimumab

Investigational new drugs, 2014-08, Vol.32 (4), p.769-773

2014

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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

Investigational new drugs, 2013-04, Vol.31 (2), p.425-434

2013

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Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

Investigational new drugs, 2014-12, Vol.32 (6), p.1144-1154

2014

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Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules

Investigational new drugs, 2014-10, Vol.32 (5), p.838-850

2014

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Effects of the combination of TRC105 and bevacizumab on endothelial cell biology

Investigational new drugs, 2014-10, Vol.32 (5), p.851-859

2014

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Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

Investigational new drugs, 2014-10, Vol.32 (5), p.904-912

2014

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A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

Investigational new drugs, 2014-08, Vol.32 (4), p.653-660

2014

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Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery

Investigational new drugs, 2013-08, Vol.31 (4), p.949-958

2013

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Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

Investigational new drugs, 2013-06, Vol.31 (3), p.545-557

2013

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Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma

Development of artemisinin compounds for cancer treatment

Ipilimumab associated hepatitis: imaging and clinicopathologic findings

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells

Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation

Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells

Kidney injuries related to ipilimumab

Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules

Effects of the combination of TRC105 and bevacizumab on endothelial cell biology

Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery

Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways

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