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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1283-1291

2019

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Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

Biochemical and biophysical research communications, 2020-11, Vol.532 (2), p.265-270

2020

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Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

Organic letters, 2016-05, Vol.18 (9), p.2166-2169

2016

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A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

Angewandte Chemie (International ed.), 2017-09, Vol.56 (38), p.11520-11524

International ed. in English, 2017

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An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126681, Article 126681

2019

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Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Journal of molecular and cellular cardiology, 2015-08, Vol.85, p.71-78

2015

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Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3968-3973

2014

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The molecular determinants of R-roscovitine block of hERG channels

PloS one, 2019-09, Vol.14 (9), p.e0217733-e0217733

2019

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A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

FEBS letters, 2012-11, Vol.586 (22), p.3996-4001

2012

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Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy

Bioorganic & medicinal chemistry letters, 2018-09, Vol.28 (17), p.3004-3008

2018

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Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels

PloS one, 2013-05, Vol.8 (5), p.e64905

2013

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Design and characterization of a novel structural class of Kv1.3 inhibitors

Bioorganic chemistry, 2020-05, Vol.98, p.103746, Article 103746

2020

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High-potency block of Kir4.1 channels by pentamidine: Molecular basis

European journal of pharmacology, 2017-11, Vol.815, p.56-63

2017

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Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

European journal of medicinal chemistry, 2015-12, Vol.106, p.50-59

2015

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Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

Toxicology letters, 2016-05, Vol.250-251, p.42-46

2016

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Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter

Biochemical pharmacology, 2015-01, Vol.93 (2), p.232

2015

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Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

Journal of applied toxicology, 2009-04, Vol.29 (3), p.183-206

2009

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Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.2023-2029

2016

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Allosteric Block of KCa2 Channels by Apamin

The Journal of biological chemistry, 2010-08, Vol.285 (35), p.27067-27077

2010

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Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel

Journal of neuroimmune pharmacology, 2017-06, Vol.12 (2), p.260-276

2017

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Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers

The Journal of biological chemistry, 2003-12, Vol.278 (50), p.50212-50216

2003

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Allosteric modulators of the hERG K+ channel Radioligand binding assays reveal allosteric characteristics of dofetilide analogs

Toxicology and applied pharmacology, 2014, Vol.274 (1), p.78-86

2014

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Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

Toxicology and applied pharmacology, 2013-12, Vol.273 (2), p.259-268

2013

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Dynamics of hERG Closure Allow Novel Insights into hERG Blocking by Small Molecules

Journal of chemical information and modeling, 2014-08, Vol.54 (8), p.2320-2333

2014

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Methotrexate, a small molecular scaffold targeting Kv1.3 channel extracellular pore region

Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

A Computational Method for Unveiling the Target Promiscuity of Pharmacologically Active Compounds

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

The molecular determinants of R-roscovitine block of hERG channels

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy

Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels

Design and characterization of a novel structural class of Kv1.3 inhibitors

High-potency block of Kir4.1 channels by pentamidine: Molecular basis

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

Monte Carlo method for predicting of cardiac toxicity: hERG blocker compounds

Mesomartoxin, a new K(v)1.2-selective scorpion toxin interacting with the channel selectivity filter

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach

Allosteric Block of KCa2 Channels by Apamin

Complexes of Peptide Blockers with Kv1.6 Pore Domain: Molecular Modeling and Studies with KcsA-Kv1.6 Channel

Single-walled Carbon Nanotubes Are a New Class of Ion Channel Blockers

Allosteric modulators of the hERG K+ channel Radioligand binding assays reveal allosteric characteristics of dofetilide analogs

Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drug's cardiac ion channel profile

Dynamics of hERG Closure Allow Novel Insights into hERG Blocking by Small Molecules

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