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PI3K inhibitors in thrombosis and cardiovascular disease

Clinical and translational medicine, 2020-01, Vol.9 (1), p.1-21

2020

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Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Scientific reports, 2021-07, Vol.11 (1), p.15308-14, Article 15308

2021

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Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

International Journal of Obesity, 2021-10, Vol.45 (10), p.2221-2229

2021

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Temporal contribution of the platelet body and balloon to thrombin generation

Haematologica (Roma), 2017-10, Vol.102 (10), p.e379

2017

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Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation

Scientific reports, 2017-06, Vol.7 (1), p.2770-12, Article 2770

2017

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CryoET reveals actin filaments within platelet microtubules

Nature communications, 2024-07, Vol.15 (1), p.5967-8, Article 5967

2024

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Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Scientific reports, 2019-02, Vol.9 (1), p.1468-1468, Article 1468

2019

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Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Nature communications, 2023-07, Vol.14 (1), p.4026-4026, Article 4026

2023

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Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets

The Journal of biological chemistry, 2009-05, Vol.284 (18), p.12339-12348

2009

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Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

Scientific reports, 2023-11, Vol.13 (1), p.21077-21077, Article 21077

2023

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Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis

International journal of molecular sciences, 2021-09, Vol.22 (19), p.10656

2021

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Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Platelets (Edinburgh), 2020-10, Vol.31 (7), p.853-859

2020

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Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis

Platelets (Edinburgh), 2022-08, Vol.33 (6), p.869-878

2022

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A phenome-wide approach to identify causal risk factors for deep vein thrombosis

BMC medical genomics, 2023-11, Vol.16 (1), p.284-284, Article 284

2023

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Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway

Blood, 2007-12, Vol.110 (13), p.4243-4252

Hers, Ingeborg

2007

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A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

The Journal of immunology (1950), 2019-09, Vol.203 (6), p.1579-1588

2019

Volltextzugriff (PDF)

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor

PloS one, 2013-06, Vol.8 (6), p.e66963-e66963

2013

Volltextzugriff (PDF)

The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

The Journal of biological chemistry, 2002-09, Vol.277 (37), p.33895-33900

2002

Volltextzugriff (PDF)

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

ACS central science, 2020-06, Vol.6 (6), p.995-1000

2020

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Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis

JCI insight, 2018-05, Vol.3 (10)

2018

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Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal

PloS one, 2015-04, Vol.10 (4), p.e0120084-e0120084

2015

Volltextzugriff (PDF)

Integrin αIIbβ3 outside-in signaling

Blood, 2017-10, Vol.130 (14), p.1607-1619

2017

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Akt signalling in health and disease

Cellular signalling, 2011-10, Vol.23 (10), p.1515-1527

2011

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Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

Journal of cell science, 2004-12, Vol.117 (Pt 25), p.5985-5993

2004

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Absence of platelet phenotype in mice lacking the motor protein myosin Va

PloS one, 2013-01, Vol.8 (1), p.e53239-e53239

2013

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PI3K inhibitors in thrombosis and cardiovascular disease

Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

Temporal contribution of the platelet body and balloon to thrombin generation

Membrane Ballooning in Aggregated Platelets is Synchronised and Mediates a Surge in Microvesiculation

CryoET reveals actin filaments within platelet microtubules

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Highly efficient platelet generation in lung vasculature reproduced by microfluidics

Protein Kinase C-mediated Phosphorylation and Activation of PDE3A Regulate cAMP Levels in Human Platelets

Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

Opposing Roles of GSK3α and GSK3β Phosphorylation in Platelet Function and Thrombosis

Carbonic Anhydrase Inhibitors suppress platelet procoagulant responses and in vivo thrombosis: Carbonic Anhydrase Inhibitors as Antithrombotics

Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis

A phenome-wide approach to identify causal risk factors for deep vein thrombosis

Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kα pathway

A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor

The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis

Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal

Integrin αIIbβ3 outside-in signaling

Akt signalling in health and disease

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

Absence of platelet phenotype in mice lacking the motor protein myosin Va

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