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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7603-7606

2006

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Genotype–phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4WHIM variants

Genes and immunity, 2022-09, Vol.23 (6), p.196-204

2022

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Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.709-716

2012

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Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1864-1868

2008

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A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm

Blood advances, 2024-07, Vol.8 (14), p.3754-3759

2024

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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Neuropharmacology, 2016-04, Vol.103, p.57-68

2016

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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7277-7280

2011

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C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (13), p.3778-3783

2007

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Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1431-1433

2009

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1434-1437

2009

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.786-791

2011

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Synthesis and structure–activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (15), p.4107-4110

2006

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Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Bioorganic & medicinal chemistry letters, 2011-09, Vol.21 (18), p.5633-5637

2011

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Sch-66336 (sarasar) and other benzocycloheptapyridyl farnesyl protein transferase inhibitors: discovery, biology and clinical observations

Current topics in medicinal chemistry, 2003-01, Vol.3 (10), p.1103-1114

2003

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The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines

Experimental cell research, 2001-01, Vol.262 (1), p.17-27

2001

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Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4446-4449

2009

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Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S 1 ′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1040-1049

2009

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Abstract 5866: Mavorixafor enhances apoptosis of tumor cells treated with ibrutinib or venetoclax in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5866-5866

2023

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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

Journal of medicinal chemistry, 1998-11, Vol.41 (24), p.4890-4902

1998

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Solid-state photochemistry. Remarkable effects of the packing of molecules in crystals on the diastereoselectivity of the intramolecular 2 + 2 photocycloaddition of a 4-(3'-butenyl)-2,5-cyclohexadien-1-one

Journal of the American Chemical Society, 1992-10, Vol.114 (22), p.8725-8727

1992

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Abstract 6093: Mavorixafor enhances efficacy of Bruton tyrosine kinase inhibitors by overcoming the protective effect of bone marrow stroma on tumor cells in Waldenström’s macroglobulinemia

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.6093-6093

2022

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Intramolecular 2 + 2 photocycloadditions of 4-(3'-alkenyl)- and 4-(3'-pentynyl)-2,5-cyclohexadien-1-ones

Journal of the American Chemical Society, 1988-08, Vol.110 (16), p.5547-5555

1988

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Exploring the Role of Bromine at C(10) of (+)-4-[2-[4-(8-Chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): The Discovery of Indolocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.3854-3864

2002

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Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres

Tetrahedron letters, 2009-09, Vol.50 (35), p.5005-5008

2009

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Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2651-2661

1999

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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist

Genotype–phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4WHIM variants

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists

Fluoroalkyl α side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2–CXCR1 dual antagonists

3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

Synthesis and structure–activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists

Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)

Sch-66336 (sarasar) and other benzocycloheptapyridyl farnesyl protein transferase inhibitors: discovery, biology and clinical observations

The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines

Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region

Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S 1 ′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

Abstract 5866: Mavorixafor enhances apoptosis of tumor cells treated with ibrutinib or venetoclax in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent

Solid-state photochemistry. Remarkable effects of the packing of molecules in crystals on the diastereoselectivity of the intramolecular 2 + 2 photocycloaddition of a 4-(3'-butenyl)-2,5-cyclohexadien-1-one

Abstract 6093: Mavorixafor enhances efficacy of Bruton tyrosine kinase inhibitors by overcoming the protective effect of bone marrow stroma on tumor cells in Waldenström’s macroglobulinemia

Intramolecular 2 + 2 photocycloadditions of 4-(3'-alkenyl)- and 4-(3'-pentynyl)-2,5-cyclohexadien-1-ones

Exploring the Role of Bromine at C(10) of (+)-4-[2-[4-(8-Chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): The Discovery of Indolocycloheptapyridine Inhibitors of Farnesyl Protein Transferase

Synthesis of functionalized hydroxy-thiophene motifs as amido- and sulfonamido-phenol bioisosteres

Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

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