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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5585-5623

2020

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Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.4052-4066

2018

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Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.2047-2057

2014

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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1153-1163

2018

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Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3627-3630

2013

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Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1804-1810

2018

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Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2225-2233

2017

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Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Antimicrobial Agents and Chemotherapy, 2005-10, Vol.49 (10), p.4305-4314

2005

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Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2003-03, Vol.46 (6), p.1016-1030

2003

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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Journal of medicinal chemistry, 2001-12, Vol.44 (25), p.4481-4491

2001

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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Bioorganic & medicinal chemistry letters, 2004-04, Vol.14 (7), p.1721-1727

2004

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Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1659-1669

2009

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Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3041-3044

2003

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Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2079-2082

2004

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Pyridopyrimidine analogues as novel adenosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2071-2074

2001

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Pharmacodynamic and receptor binding changes during chronic lorazepam administration

Pharmacology, biochemistry and behavior, 2001-05, Vol.69 (1), p.1-8

2001

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The P450 Catalytic Cycle and Oxygenation Mechanism

Drug metabolism reviews, 1998-01, Vol.30 (4), p.739-786

1998

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A new class of potent non-imidazole H 3 antagonists: 2-aminoethylbenzofurans

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.689-693

2004

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Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice

The Journal of pharmacology and experimental therapeutics, 1998-04, Vol.285 (1), p.271

1998

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In vitro Optimization of Structure Activity Relationships of Analogues of A‐331440 Combining Radioligand Receptor Binding Assays and Micronucleus Assays of Potential Antiobesity Histamine H 3 Receptor Antagonists

Basic & clinical pharmacology & toxicology, 2004-09, Vol.95 (3), p.144-152

2004

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D‐Amino Acid Homopiperazine Amides: Discovery of A‐320436, a Potent and Selective Non‐Imidazole Histamine H 3 ‐Receptor Antagonist

Archiv der Pharmazie (Weinheim), 2004-04, Vol.337 (4), p.219-229

2004

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Lorazepam Attenuates the Behavioral Effects of Dizocilpine

Pharmacology, biochemistry and behavior, 1999-01, Vol.62 (1), p.103-110

1999

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In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration

Journal of psychopharmacology (Oxford), 1999, Vol.13 (3), p.211-218

1999

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Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)

Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability

Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Methylpyrrole inhibitors of BET bromodomains

Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro

Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators

Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazines

Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists

Pyridopyrimidine analogues as novel adenosine kinase inhibitors

Pharmacodynamic and receptor binding changes during chronic lorazepam administration

The P450 Catalytic Cycle and Oxygenation Mechanism

A new class of potent non-imidazole H 3 antagonists: 2-aminoethylbenzofurans

Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice

In vitro Optimization of Structure Activity Relationships of Analogues of A‐331440 Combining Radioligand Receptor Binding Assays and Micronucleus Assays of Potential Antiobesity Histamine H 3 Receptor Antagonists

D‐Amino Acid Homopiperazine Amides: Discovery of A‐320436, a Potent and Selective Non‐Imidazole Histamine H 3 ‐Receptor Antagonist

Lorazepam Attenuates the Behavioral Effects of Dizocilpine

In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration

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