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New Pharmacological Approaches for Rare Diseases

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7275

Ortega-Gutiérrez, Silvia

2023

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Small-Molecule Therapeutic Perspectives for the Treatment of Progeria

International journal of molecular sciences, 2021-07, Vol.22 (13), p.7190

2021

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Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

JNCI : Journal of the National Cancer Institute, 2015-06, Vol.107 (6), p.djv077-djv077

2015

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Chemical Probes for the Recognition of Cannabinoid Receptors in Native Systems

Angewandte Chemie (International ed.), 2012-07, Vol.51 (28), p.6896-6899

International ed. in English, 2012

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A new fluorescent probe for the visualization of progerin

Bioorganic chemistry, 2024-01, Vol.142, p.106967-106967, Article 106967

2024

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The expression of cannabinoid receptor 1 is significantly increased in atopic patients

Journal of allergy and clinical immunology, 2014-03, Vol.133 (3), p.926-929.e2

2014

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Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors

Chemistry : a European journal, 2016-01, Vol.22 (4), p.1313-1321

2016

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The medicinal chemistry of agents targeting monoacylglycerol lipase

Current topics in medicinal chemistry, 2008-02, Vol.8 (3), p.231

2008

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Characterization of an anandamide degradation system in prostate epithelial PC‐3 cells: synthesis of new transporter inhibitors as tools for this study

British journal of pharmacology, 2004-02, Vol.141 (3), p.457-467

2004

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New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5013-5023

2012

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Therapeutic perspectives of inhibitors of endocannabinoid degradation

Current drug targets. CNS & neurological disorders, 2005-12, Vol.4 (6), p.697

Ortega-Gutiérrez, Silvia

2005

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CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches

Mini reviews in medicinal chemistry, 2005-07, Vol.5 (7), p.651

2005

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New Inhibitors of Angiogenesis with Antitumor Activity in Vivo

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3757-3766

2015

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Structure–Activity Relationship of a New Series of Reversible Dual Monoacylglycerol Lipase/Fatty Acid Amide Hydrolase Inhibitors

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.824-836

2012

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Development of Endocannabinoid-Based Chemical Probes for the Study of Cannabinoid Receptors

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.5265-5269

2011

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Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4505-4508

2001

Volltextzugriff (PDF)

Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy

Journal of medicinal chemistry, 2011-02, Vol.54 (4), p.1096-1100

2011

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Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

European journal of medicinal chemistry, 2003-04, Vol.38 (4), p.403-412

2003

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A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

Breast cancer research : BCR, 2011-01, Vol.13 (6), p.R131-R131, Article R131

2011

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A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

Journal of neurology, 2016-07, Vol.263 (7), p.1390-1400

2016

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Involvement of cannabinoids in cellular proliferation

Mini reviews in medicinal chemistry, 2005-01, Vol.5 (1), p.97

2005

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Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1512-1522

2003

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A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

Journal of neuroimmune pharmacology, 2015-06, Vol.10 (2), p.309-317

2015

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VR1 receptor modulators as potential drugs for neuropathic pain

Mini reviews in medicinal chemistry, 2003-11, Vol.3 (7), p.729

2003

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New Pharmacological Approaches for Rare Diseases

Small-Molecule Therapeutic Perspectives for the Treatment of Progeria

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

Chemical Probes for the Recognition of Cannabinoid Receptors in Native Systems

A new fluorescent probe for the visualization of progerin

The expression of cannabinoid receptor 1 is significantly increased in atopic patients

Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors

The medicinal chemistry of agents targeting monoacylglycerol lipase

A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration

Characterization of an anandamide degradation system in prostate epithelial PC‐3 cells: synthesis of new transporter inhibitors as tools for this study

New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

Therapeutic perspectives of inhibitors of endocannabinoid degradation

CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches

New Inhibitors of Angiogenesis with Antitumor Activity in Vivo

Structure–Activity Relationship of a New Series of Reversible Dual Monoacylglycerol Lipase/Fatty Acid Amide Hydrolase Inhibitors

Development of Endocannabinoid-Based Chemical Probes for the Study of Cannabinoid Receptors

Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors

Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

Involvement of cannabinoids in cellular proliferation

Design, Synthesis, and Biological Evaluation of New Inhibitors of the Endocannabinoid Uptake: Comparison with Effects on Fatty Acid Amidohydrolase

A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol 3-Kinase (PI3K)/AKT and the Mammalian Target of Rapamycin (MTOR) Pathways

VR1 receptor modulators as potential drugs for neuropathic pain

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