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Reconstructing Ancient Proteins to Understand the Causes of Structure and Function

Annual review of biophysics, 2017-05, Vol.46, p.247

2017

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Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

Analytical chemistry (Washington), 2015-04, Vol.87 (8), p.4370-4376

2015

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Structural basis for lipid and copper regulation of the ABC transporter MsbA

Nature communications, 2022-11, Vol.13 (1), p.7291-11, Article 7291

2022

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Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus

Nature communications, 2023-07, Vol.14 (1), p.4056-4056, Article 4056

2023

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Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus

mBio, 2024-03, Vol.15 (3), p.e0331423-e0331423

2024

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The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression

Nature communications, 2024-01, Vol.15 (1), p.318-318, Article 318

2024

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A hydrophobic ratchet entrenches molecular complexes

Nature (London), 2020-12, Vol.588 (7838), p.503-508

2020

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An ultra-stable gold-coordinated protein cage displaying reversible assembly

Nature (London), 2019-05, Vol.569 (7756), p.438-442

2019

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ATPase Activity of Bacillus subtilis RecA Affects the Dynamic Formation of RecA Filaments at DNA Double Strand Breaks

mSphere, 2022-12, Vol.7 (6), p.e0041222-e0041222

2022

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Simple mechanisms for the evolution of protein complexity

Protein science, 2022-11, Vol.31 (11), p.e4449-n/a

2022

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The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity

Proceedings of the National Academy of Sciences - PNAS, 2014-04, Vol.111 (16), p.5771-5771

2014

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Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"

Science (American Association for the Advancement of Science), 2020-11, Vol.370 (6519)

2020

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Evolution of protein specificity: insights from ancestral protein reconstruction

Current opinion in structural biology, 2017-12, Vol.47, p.113-122

2017

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Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions

Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6378), p.930-935

2018

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Fortuitously compatible protein surfaces primed allosteric control in cyanobacterial photoprotection

Nature ecology & evolution, 2023-05, Vol.7 (5), p.756

2023

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Non-adaptive complexity and biochemical function

Current opinion in structural biology, 2022-04, Vol.73, p.102339-102339, Article 102339

2022

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Origin of complexity in haemoglobin evolution

Nature (London), 2020-05, Vol.581 (7809), p.480-485

2020

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Evolution of increased complexity and specificity at the dawn of form I Rubiscos

Science (American Association for the Advancement of Science), 2022-10, Vol.378 (6616), p.155-160

2022

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It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate

The Journal of biological chemistry, 2018-12, Vol.293 (51), p.19511-19521

2018

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Evidence for an early green/red photocycle that precedes the diversification of GAF domain photoreceptor cyanobacteriochromes

Photochemical & photobiological sciences, 2023-06, Vol.22 (6), p.1415-1427

2023

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Dynamical structure of αB-crystallin

Progress in biophysics and molecular biology, 2014-07, Vol.115 (1), p.11-20

2014

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Evolution-inspired engineering of nonribosomal peptide synthetases

Science (American Association for the Advancement of Science), 2024-03, Vol.383 (6689), p.eadg4320-eadg4320

2024

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Emergence of fractal geometries in the evolution of a metabolic enzyme

Nature (London), 2024-04, Vol.628 (8009), p.894-900

2024

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Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

Cell reports (Cambridge), 2023-11, Vol.42 (11), p.113375-113375, Article 113375

2023

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C-terminal interactions mediate the quaternary dynamics of αB-crystallin

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2013-05, Vol.368 (1617), p.20110405

2013

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Reconstructing Ancient Proteins to Understand the Causes of Structure and Function

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

Structural basis for lipid and copper regulation of the ABC transporter MsbA

Molecular basis and design principles of switchable front-rear polarity and directional migration in Myxococcus xanthus

Two distinct ferredoxins are essential for nitrogen fixation by the iron nitrogenase in Rhodobacter capsulatus

The virulence regulator VirB from Shigella flexneri uses a CTP-dependent switch mechanism to activate gene expression

A hydrophobic ratchet entrenches molecular complexes

An ultra-stable gold-coordinated protein cage displaying reversible assembly

ATPase Activity of Bacillus subtilis RecA Affects the Dynamic Formation of RecA Filaments at DNA Double Strand Breaks

Simple mechanisms for the evolution of protein complexity

The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity

Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"

Evolution of protein specificity: insights from ancestral protein reconstruction

Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions

Fortuitously compatible protein surfaces primed allosteric control in cyanobacterial photoprotection

Non-adaptive complexity and biochemical function

Origin of complexity in haemoglobin evolution

Evolution of increased complexity and specificity at the dawn of form I Rubiscos

It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate

Evidence for an early green/red photocycle that precedes the diversification of GAF domain photoreceptor cyanobacteriochromes

Dynamical structure of αB-crystallin

Evolution-inspired engineering of nonribosomal peptide synthetases

Emergence of fractal geometries in the evolution of a metabolic enzyme

Ion binding with charge inversion combined with screening modulates DEAD box helicase phase transitions

C-terminal interactions mediate the quaternary dynamics of αB-crystallin

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