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Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

Angewandte Chemie (International ed.), 2012-01, Vol.51 (5), p.1114-1122

International ed. in English, 2012

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Malonylation of GAPDH is an inflammatory signal in macrophages

Nature communications, 2019-01, Vol.10 (1), p.338-11, Article 338

2019

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Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5887-5900

2012

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Synthesis of chiral non-racemic substituted vinyl aziridines

Tetrahedron letters, 2008-08, Vol.49 (32), p.4768-4770

2008

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Leitstruktur‐orientierte Synthese: eine Alternative für die Synthesechemie

Angewandte Chemie, 2012-01, Vol.124 (5), p.1140-1149

2012

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Synthesis of tricyclic pyridones by radical cyclization

Tetrahedron letters, 1999-05, Vol.40 (21), p.4073-4076

1999

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A Turing Test for Molecular Generators

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11964-11971

2020

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Synthesis and Conformational Dynamics of Tricyclic Pyridones Containing a Fused Seven-Membered Ring

Journal of organic chemistry, 2002-12, Vol.67 (26), p.9354-9360

2002

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In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice

The Journal of pharmacology and experimental therapeutics, 2019-09, Vol.370 (3), p.786

2019

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Synthesis of Zaragozic Acid A/Squalestatin S1

Chemistry : a European journal, 1995-10, Vol.1 (7), p.467-494

1995

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry

Journal of biomolecular screening, 2016-02, Vol.21 (2), p.145-155

2016

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Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Nature (London), 2000-06, Vol.405 (6787), p.689-694

2000

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Leitstruktur-orientierte Synthese: eine Alternative für die Synthesechemie

Angewandte Chemie, 2012-01, Vol.124 (5), p.1140-1149

2012

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L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Biochemistry (Easton), 2000-08, Vol.39 (30), p.8698-8704

2000

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Direct Synthesis of Substituted Vinyl Aziridines

Synlett, 2007-11, Vol.2007 (18), p.2879-2881

2007

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Catalytic Site-Directed γ-Secretase Complex Inhibitors Do Not Discriminate Pharmacologically between Notch S3 and β-APP Cleavages

Biochemistry (Easton), 2003-06, Vol.42 (24), p.7580-7586

2003

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

The Journal of biological chemistry, 2001-11, Vol.276 (48), p.45394-45402

2001

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In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

Biochemistry (Easton), 2003-07, Vol.42 (27), p.8133-8142

2003

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New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-Catalyzed Cross-Coupling of Imidoyl Chlorides with Organoboronic Acids

Journal of organic chemistry, 2003-04, Vol.68 (7), p.2844-2852

2003

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Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Journal of neurochemistry, 2004-09, Vol.90 (6), p.1312-1320

2004

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Saturated nitrogen heterocycles

Contemporary organic synthesis, 1997, Vol.4 (5), p.387

Nadin, Alan

1997

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γ-Secretase: characterization and implication for Alzheimer disease therapy

Neurobiology of aging, 2002-11, Vol.23 (6), p.1023-1030

2002

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Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target Î³-Secretase at a Novel Site

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419

2004

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Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

The Journal of biological chemistry, 2004-10, Vol.279 (42), p.43419-43426

2004

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Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

Malonylation of GAPDH is an inflammatory signal in macrophages

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Synthesis of chiral non-racemic substituted vinyl aziridines

Leitstruktur‐orientierte Synthese: eine Alternative für die Synthesechemie

Synthesis of tricyclic pyridones by radical cyclization

A Turing Test for Molecular Generators

Synthesis and Conformational Dynamics of Tricyclic Pyridones Containing a Fused Seven-Membered Ring

In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice

Synthesis of Zaragozic Acid A/Squalestatin S1

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism

A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Leitstruktur-orientierte Synthese: eine Alternative für die Synthesechemie

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Direct Synthesis of Substituted Vinyl Aziridines

Catalytic Site-Directed γ-Secretase Complex Inhibitors Do Not Discriminate Pharmacologically between Notch S3 and β-APP Cleavages

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand

New Synthesis of 1,3-Dihydro-1,4-benzodiazepin-2(2H)-ones and 3-Amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-Catalyzed Cross-Coupling of Imidoyl Chlorides with Organoboronic Acids

Conserved residues within the putative active site of γ‐secretase differentially influence enzyme activity and inhibitor binding

Saturated nitrogen heterocycles

γ-Secretase: characterization and implication for Alzheimer disease therapy

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target Î³-Secretase at a Novel Site

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

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