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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4432-4441

2008

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Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1753-1769

2014

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Transition States of Epoxidations: Diradical Character, Spiro Geometries, Transition State Flexibility, and the Origins of Stereoselectivity

Journal of the American Chemical Society, 1997-10, Vol.119 (42), p.10147-10152

1997

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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115232-115232, Article 115232

2020

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Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO2 Adduct: Density Functional Theory Transition Structures and Energetics

Journal of the American Chemical Society, 1996-12, Vol.118 (51), p.13002-13006

1996

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Identification of a New Class of Glucokinase Activators through Structure-Based Design

Journal of medicinal chemistry, 2013-10, Vol.56 (19), p.7669-7678

2013

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Discovery of 2‑Pyridylureas as Glucokinase Activators

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8180-8186

2014

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Synthesis of (.+-.)-7,8-Epoxy-4-basmen-6-one by a Transannular Cyclization Strategy

Journal of the American Chemical Society, 1995-03, Vol.117 (11), p.3057-3083

1995

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1709-1718

2004

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Synthesis of (.+-.)-7,8-epoxy-4-basmen-6-one by a transannular cyclization strategy

Journal of the American Chemical Society, 1993-08, Vol.115 (17), p.7926-7927

1993

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Stereoselectivities of Nucleophilic Additions to Cycloheptanones. Experimental and Theoretical Studies and General Purpose Force Field for the Prediction of Nucleophilic Addition Stereoselectivities

Journal of organic chemistry, 1998-05, Vol.63 (10), p.3196-3203

1998

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Abstract 1464: Pre-clinical characterization of potent and selective next-generation RET inhibitors

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1464-1464

2021

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Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer

JCO precision oncology, 2019-09 (3), p.1-7

2019

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Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO2 Adduct: Density Functional Theory Transition Structures and Energetics J. Am. Chem. Soc. 1996, 118, 13002

Journal of the American Chemical Society, 1997-03, Vol.119 (12), p.2964-2964

1997

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Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO 2 Adduct: Density Functional Theory Transition Structures and Energetics J. Am. Chem. Soc. 1996 , 118 , 13002

Journal of the American Chemical Society, 1997-03, Vol.119 (12), p.2964-2964

1997

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Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO 2 Adduct: Density Functional Theory Transition Structures and Energetics

Journal of the American Chemical Society, 1996-01, Vol.118 (51), p.13002-13006

1996

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Stereoselective Synthesis of Polycyclic Ring Systems via the Tandem Diels-Alder Reaction

Journal of organic chemistry, 1994-11, Vol.59 (23), p.6879-6881

1994

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4401-4410

2019

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Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease

Transition States of Epoxidations: Diradical Character, Spiro Geometries, Transition State Flexibility, and the Origins of Stereoselectivity

Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator

Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO2 Adduct: Density Functional Theory Transition Structures and Energetics

Identification of a New Class of Glucokinase Activators through Structure-Based Design

Discovery of 2‑Pyridylureas as Glucokinase Activators

Synthesis of (.+-.)-7,8-Epoxy-4-basmen-6-one by a Transannular Cyclization Strategy

Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization

Synthesis of (.+-.)-7,8-epoxy-4-basmen-6-one by a transannular cyclization strategy

Stereoselectivities of Nucleophilic Additions to Cycloheptanones. Experimental and Theoretical Studies and General Purpose Force Field for the Prediction of Nucleophilic Addition Stereoselectivities

Abstract 1464: Pre-clinical characterization of potent and selective next-generation RET inhibitors

Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer

Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO2 Adduct: Density Functional Theory Transition Structures and Energetics J. Am. Chem. Soc. 1996, 118, 13002

Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO 2 Adduct: Density Functional Theory Transition Structures and Energetics J. Am. Chem. Soc. 1996 , 118 , 13002

Radical and Concerted Mechanisms in Oxidations of Amines, Sulfides, and Alkenes by Peroxynitrite, Peroxynitrous Acid, and the Peroxynitrite−CO 2 Adduct: Density Functional Theory Transition Structures and Energetics

Stereoselective Synthesis of Polycyclic Ring Systems via the Tandem Diels-Alder Reaction

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

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