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Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9)

2021

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Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging

Nature communications, 2020-06, Vol.11 (1), p.2933-12, Article 2933

2020

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A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Nature communications, 2018-05, Vol.9 (1), p.2106-9, Article 2106

2018

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Structural insight into the stabilization of microtubules by taxanes

eLife, 2023-03, Vol.12

2023

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Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function

International journal of molecular sciences, 2022-03, Vol.23 (7), p.3448

2022

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Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

Frontiers in pharmacology, 2024-08, Vol.15, p.1428409

2024

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Structural model for differential cap maturation at growing microtubule ends

eLife, 2020-03, Vol.9

2020

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N -alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Cancer cell international, 2020-05, Vol.20 (1), p.170-16, Article 170

2020

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Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Cancers, 2020-08, Vol.12 (8), p.2196

2020

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Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

iScience, 2019-11, Vol.21, p.95-109

2019

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Liaison alcaline : Pals entice non-endosomal ESCRTs to the plasma membrane for pH signaling

Current opinion in microbiology, 2014-12, Vol.22, p.49-59

2014

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Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.9227-9259

2024

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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

European journal of medicinal chemistry, 2023-11, Vol.259, p.115668, Article 115668

2023

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PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.2619-2630

2024

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Studies toward the Synthesis of an Oxazole-Based Analog of (−)-Zampanolide

Organic letters, 2021-03, Vol.23 (6), p.2238-2242

2021

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Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

European journal of medicinal chemistry, 2022-05, Vol.235, p.114274-114274, Article 114274

2022

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Chemical modulation of microtubule structure through the laulimalide/peloruside site

Structure (London), 2023-01, Vol.31 (1), p.88-99.e5

2023

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Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library

Bioorganic chemistry, 2021-10, Vol.115, p.105135-105135, Article 105135

2021

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Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation

ACS chemical biology, 2016-11, Vol.11 (11), p.3024-3034

2016

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Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

European journal of medicinal chemistry, 2017-09, Vol.137, p.488-503

2017

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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

European journal of medicinal chemistry, 2023-11, Vol.259, p.115668-115668

2023

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Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

Eukaryotic cell, 2015-06, Vol.14 (6), p.545-553

2015

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Abstract 6239: PM534 is a novel microtubule-destabilizing agent with high affinity and potent antineoplastic properties

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6239-6239

2023

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Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F‑Actin

Journal of organic chemistry, 2015-09, Vol.80 (17), p.8511-8519

2015

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Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Structural insight into the stabilization of microtubules by taxanes

Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function

Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents

Structural model for differential cap maturation at growing microtubule ends

N -alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia

Liaison alcaline : Pals entice non-endosomal ESCRTs to the plasma membrane for pH signaling

Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin

Studies toward the Synthesis of an Oxazole-Based Analog of (−)-Zampanolide

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Chemical modulation of microtubule structure through the laulimalide/peloruside site

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library

Aggregated Compound Biological Signatures Facilitate Phenotypic Drug Discovery and Target Elucidation

Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis

Abstract 6239: PM534 is a novel microtubule-destabilizing agent with high affinity and potent antineoplastic properties

Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F‑Actin

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