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Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance

PloS one, 2015-05, Vol.10 (5), p.e0126350

2015

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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (10), p.3865-3870

2014

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Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

PloS one, 2016-12, Vol.11 (12), p.e0167485-e0167485

2016

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Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases

Journal of fungi (Basel), 2021-01, Vol.7 (2), p.67

2021

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Azole Combinations and Multi-Targeting Drugs That Synergistically Inhibit Candidozyma auris

Journal of fungi (Basel), 2024-10, Vol.10 (10), p.698

2024

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The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1508-1515

2012

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Exploring Cryptococcus neoformans CYP51 and Its Cognate Reductase as a Drug Target

Journal of fungi (Basel), 2022-11, Vol.8 (12), p.1256

2022

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Functional Expression of Recombinant Candida auris Proteins in Saccharomyces cerevisiae Enables Azole Susceptibility Evaluation and Drug Discovery

Journal of fungi (Basel), 2023-01, Vol.9 (2), p.168

2023

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Correction: Monk, B.C.; Keniya, M.V. Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases. J. Fungi 2021, 7 , 67

Journal of fungi (Basel), 2021-11, Vol.7 (12), p.1011

2021

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Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host

Journal of fungi (Basel), 2022-01, Vol.8 (1), p.69

2022

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Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris

Journal of fungi (Basel), 2023-06, Vol.9 (6), p.663

2023

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Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Antimicrobial agents and chemotherapy, 2018-11, Vol.62 (11)

2018

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Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Biochimica et biophysica acta. Proteins and proteomics, 2020-03, Vol.1868 (3), p.140206, Article 140206

2020

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Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate

Journal of fungi (Basel), 2021-10, Vol.7 (11), p.897

2021

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Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-Associated Human ATP-Binding Cassette Transporter ABCB5

Molecular pharmaceutics, 2014-10, Vol.11 (10), p.3452-3462

2014

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Antimicrobial agents and chemotherapy, 2015-08, Vol.59 (8), p.4982-4989

2015

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Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

Scientific reports, 2016-05, Vol.6 (1), p.26213-26213, Article 26213

2016

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Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

Antimicrobial agents and chemotherapy, 2018-11, Vol.62 (11)

2018

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Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis

PLoS pathogens, 2024-09, Vol.20 (9), p.e1012521

2024

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Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Antimicrobial agents and chemotherapy, 2019-01, Vol.63 (1)

2019

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Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Antimicrobial agents and chemotherapy, 2018-03, Vol.62 (3)

2018

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Targeting efflux pumps to overcome antifungal drug resistance

Future medicinal chemistry, 2016-08, Vol.8 (12), p.1485-1501

2016

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Functional Expression of Recombinant ICandida auris/I Proteins in ISaccharomyces cerevisiae/I Enables Azole Susceptibility Evaluation and Drug Discovery

Journal of fungi (Basel), 2023-01, Vol.9 (2)

2023

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Exploring ICryptococcus neoformans/I CYP51 and Its Cognate Reductase as a Drug Target

Journal of fungi (Basel), 2022-11, Vol.8 (12)

2022

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Clorgyline Analogs Synergize with Azoles against Drug Efflux in ICandida auris/I

Journal of fungi (Basel), 2023-06, Vol.9 (6)

2023

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Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases

Azole Combinations and Multi-Targeting Drugs That Synergistically Inhibit Candidozyma auris

The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

Exploring Cryptococcus neoformans CYP51 and Its Cognate Reductase as a Drug Target

Functional Expression of Recombinant Candida auris Proteins in Saccharomyces cerevisiae Enables Azole Susceptibility Evaluation and Drug Discovery

Correction: Monk, B.C.; Keniya, M.V. Roles for Structural Biology in the Discovery of Drugs and Agrochemicals Targeting Sterol 14α-Demethylases. J. Fungi 2021, 7 , 67

Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host

Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate

Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-Associated Human ATP-Binding Cassette Transporter ABCB5

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery

Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Targeting efflux pumps to overcome antifungal drug resistance

Functional Expression of Recombinant ICandida auris/I Proteins in ISaccharomyces cerevisiae/I Enables Azole Susceptibility Evaluation and Drug Discovery

Exploring ICryptococcus neoformans/I CYP51 and Its Cognate Reductase as a Drug Target

Clorgyline Analogs Synergize with Azoles against Drug Efflux in ICandida auris/I

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