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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Nature (London), 2013-09, Vol.501 (7466), p.232-236

2013

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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1122-1135

2019

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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

The Journal of immunology (1950), 2013-09, Vol.191 (5), p.2205-2216

2013

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Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Journal of medicinal chemistry, 2013-08, Vol.56 (16), p.6413-6433

2013

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Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (12), p.4921-4937

2013

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Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

Journal of the American Chemical Society, 2005-08, Vol.127 (31), p.11159-11175

2005

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Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4875-4885

2013

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Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

Journal of the American Chemical Society, 2005-08, Vol.127 (31), p.11176-11183

2005

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Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.337-343

2014

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Discovery of a Biologically Active Thiostrepton Fragment

Journal of the American Chemical Society, 2005-11, Vol.127 (43), p.15042-15044

2005

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Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126658-126658, Article 126658

2019

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Measuring Nad + Levels in Mouse Blood and Tissue Samples Via A Surrogate Matrix Approach Using LC–MS/MS

Bioanalysis, 2014-06, Vol.6 (11), p.1445-1457

2014

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Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial

Journal of allergy and clinical immunology, 2021-09, Vol.148 (3), p.783-789

2021

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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Toxicological sciences, 2015-03, Vol.144 (1), p.163-172

2015

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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (12), p.1522-1531

2019

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Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Journal of medicinal chemistry, 2012-06, Vol.55 (12), p.5901-5921

2012

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Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (18), p.8345-8368

2016

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Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (8), p.1121-1130

2014

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Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Science translational medicine, 2018-11, Vol.10 (468)

2018

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A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery

Journal of computer-aided molecular design, 2015-04, Vol.29 (4), p.327-338

2015

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Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4764-4785

2013

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Kilogram Synthesis of (S)-3-Aminopyran from l-Glutamic Acid

Synlett, 2013-05, Vol.24 (8), p.987-990

2013

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Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.6176-6193

2012

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Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.770-792

2014

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Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (20), p.5488-5497

2013

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Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Total Synthesis of Thiostrepton. Retrosynthetic Analysis and Construction of Key Building Blocks

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors

Discovery of a Biologically Active Thiostrepton Fragment

Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma

Measuring Nad + Levels in Mouse Blood and Tissue Samples Via A Surrogate Matrix Approach Using LC–MS/MS

Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial

Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase

Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase

Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery

Identification of C‑2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

Kilogram Synthesis of (S)-3-Aminopyran from l-Glutamic Acid

Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

Fragment-Based Identification of Amides Derived from trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

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