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The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia

Leukemia, 2017-09, Vol.31 (9), p.2000-2005

2017

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Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs

Leukemia, 2012-06, Vol.26 (6), p.1329-1337

2012

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Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

Haematologica (Roma), 2012-04, Vol.97 (4), p.534-537

2012

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Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML 1 and Sp1 binding motifs

Leukemia, 2012, Vol.26 (6), p.1329-1337

2012

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“Long COVID‐19” of Researchers: What to Do Next?

HemaSphere, 2022-01, Vol.6 (1), p.e673-n/a

2022

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

Cell reports (Cambridge), 2018-03, Vol.22 (13), p.3641-3659

2018

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Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

Leukemia, 2020-05, Vol.34 (5), p.1266-1277

2020

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Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

Nature communications, 2022-10, Vol.13 (1), p.6220-6220, Article 6220

2022

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Effect of the COVID‐19 Pandemic on Laboratory and Clinical Research: A Testimony and a Call to Action From Researchers

HemaSphere, 2020-12, Vol.4 (6), p.e499-n/a

2020

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Robust CRISPR‐Cas9 Genetic Editing of Primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Cells

HemaSphere, 2023-06, Vol.7 (6), p.e909-n/a

2023

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Molecular & cellular oncology, 2018-07, Vol.5 (4), p.e1481813-e1481813

2018

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Biological, prognostic, and therapeutic impact of the epigenome in CLL

Seminars in hematology, 2024-06, Vol.61 (3), p.172-180

2024

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LSD1: biologic roles and therapeutic targeting

Epigenomics, 2016-08, Vol.8 (8), p.1103-1116

2016

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CRISPR-Cas9 Genome Editing of Primary Chronic Lymphocytic Leukemia Cells

Blood, 2022-11, Vol.140 (Supplement 1), p.9849-9850

2022

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IRF2 Regulates De Novo Active Chromatin Regions and Participates in the Development and Pathogenesis of Multiple Myeloma

Blood, 2023-11, Vol.142 (Supplement 1), p.1928-1928

2023

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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

Cancer cell, 2023-12, Vol.41 (12), p.2136-2153.e13

2023

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Development of a Novel Chromatin Activation Score As a Powerful Independent Prognostic Factor in Chronic Lymphocytic Leukemia

Blood, 2022-11, Vol.140 (Supplement 1), p.4123-4124

2022

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Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia

Blood, 2022-11, Vol.140 (Supplement 1), p.8774-8775

2022

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HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

Oncogene, 2022-10, Vol.41 (44), p.4841-4854

2022

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HDAC Inhibitors As Novel Targeted Therapies for NUP98-HOXA9 AML Patients

Blood, 2016-12, Vol.128 (22), p.2685-2685

2016

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Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (14), p.3190-3195

2017

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Chromatin Modifications Induced by the AML1/ETO Fusion Protein Reversibly Silence Its Genomic Targets Through AML1 and Sp1 Binding Motifs

Blood, 2011-11, Vol.118 (21), p.2422-2422

2011

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Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Blood, 2014-03, Vol.123 (11), p.1729-1738

2014

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Abstract PO-023: CD70 deregulation in follicular lymphoma at diagnosis is associated with relapse and opens new avenues for dual CD19-CD70 CAR-T therapy

Blood cancer discovery, 2024-06, Vol.5 (3_Supplement), p.PO-023-PO-023

2024

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Humans
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Leukemia
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Acute Myeloid Leukemia
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Leukemia, Myeloid, Acute - Genetics
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Leukemia, Myeloid, Acute - Metabolism
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Histone Demethylases - Antagonists & Inhibitors
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Internal Medicine
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Lsd1
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Medicine
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Medicine & Public Health
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Medicine/public Health
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Transcription Factors
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The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML1 and Sp1 binding motifs

Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

Chromatin modifications induced by the AML1-ETO fusion protein reversibly silence its genomic targets through AML 1 and Sp1 binding motifs

“Long COVID‐19” of Researchers: What to Do Next?

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

Effect of the COVID‐19 Pandemic on Laboratory and Clinical Research: A Testimony and a Call to Action From Researchers

Robust CRISPR‐Cas9 Genetic Editing of Primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma Cells

S142: FOXO1‐RICTOR AXIS INDUCES ADAPTIVE INCREASE IN AKT ACTIVITY DURING BCR INHIBITOR THERAPY IN CLL: IMPLICATIONS FOR COMBINATION THERAPY

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Biological, prognostic, and therapeutic impact of the epigenome in CLL

LSD1: biologic roles and therapeutic targeting

CRISPR-Cas9 Genome Editing of Primary Chronic Lymphocytic Leukemia Cells

IRF2 Regulates De Novo Active Chromatin Regions and Participates in the Development and Pathogenesis of Multiple Myeloma

Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

Development of a Novel Chromatin Activation Score As a Powerful Independent Prognostic Factor in Chronic Lymphocytic Leukemia

Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia

HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

HDAC Inhibitors As Novel Targeted Therapies for NUP98-HOXA9 AML Patients

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

Chromatin Modifications Induced by the AML1/ETO Fusion Protein Reversibly Silence Its Genomic Targets Through AML1 and Sp1 Binding Motifs

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Abstract PO-023: CD70 deregulation in follicular lymphoma at diagnosis is associated with relapse and opens new avenues for dual CD19-CD70 CAR-T therapy

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