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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

PloS one, 2018-05, Vol.13 (5), p.e0196791-e0196791

2018

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Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Cell metabolism, 2012-06, Vol.15 (6), p.905-917

2012

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A Potent d‑Protein Antagonist of VEGF‑A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

ACS chemical biology, 2016-04, Vol.11 (4), p.1058-1065

2016

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Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.24155-24167

2009

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Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag

Journal of the American Chemical Society, 2014-01, Vol.136 (4), p.1194-1197

2014

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Development of human-machine language interfaces for the visual analysis of complex biologics and RNA modalities and associated experimental data

AAPS open, 2023-03, Vol.9 (1), p.5-11, Article 5

2023

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Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Frontiers in pharmacology, 2017-11, Vol.8, p.838-838

2017

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Structure-guided Discovery of Dual-recognition Chemibodies

Scientific reports, 2018-05, Vol.8 (1), p.7570-9, Article 7570

2018

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Progress and challenges in the optimization of toxin peptides for development as pain therapeutics

Current opinion in chemical biology, 2017-06, Vol.38, p.70-79

2017

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Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

Journal of pharmacological and toxicological methods, 2009-05, Vol.59 (3), p.171-180

2009

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Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein

Science (American Association for the Advancement of Science), 2003-02, Vol.299 (5608), p.884-887

2003

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Probing the S100 protein family through genomic and functional analysis

Genomics (San Diego, Calif.), 2004-07, Vol.84 (1), p.10-22

2004

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Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2299-2314

2015

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Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2299-2314

2015

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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2704-2717

2016

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Process development of a SARS-CoV-2 nanoparticle vaccine

Process biochemistry (1991), 2023-06, Vol.129, p.241-256

2023

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Metal-Free Polymer-Based Affinity Medium for Selective Purification of His6-Tagged Proteins

Biomacromolecules, 2021-04, Vol.22 (4), p.1695-1705

2021

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Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9500-9512

2018

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Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3427-3438

2021

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Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127499-127499, Article 127499

2020

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Accelerated Chemical Synthesis of Peptides and Small Proteins

Proceedings of the National Academy of Sciences - PNAS, 1999-02, Vol.96 (4), p.1181-1186

1999

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6784-6802

2015

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4866-4871

2015

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Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx‑1

ACS chemical biology, 2019-01, Vol.14 (1), p.118-130

2019

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Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1111-1121

2019

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

A Potent d‑Protein Antagonist of VEGF‑A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

Epitope Discovery for a Synthetic Polymer Nanoparticle: A New Strategy for Developing a Peptide Tag

Development of human-machine language interfaces for the visual analysis of complex biologics and RNA modalities and associated experimental data

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Structure-guided Discovery of Dual-recognition Chemibodies

Progress and challenges in the optimization of toxin peptides for development as pain therapeutics

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein

Probing the S100 protein family through genomic and functional analysis

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1

Process development of a SARS-CoV-2 nanoparticle vaccine

Metal-Free Polymer-Based Affinity Medium for Selective Purification of His6-Tagged Proteins

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation

Accelerated Chemical Synthesis of Peptides and Small Proteins

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx‑1

Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species

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