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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Nature communications, 2016-11, Vol.7 (1), p.13312-12, Article 13312

2016

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Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Nature chemical biology, 2018-02, Vol.14 (2), p.163-170

2018

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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Cancer discovery, 2019-07, Vol.9 (7), p.926-943

2019

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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

Molecular cancer therapeutics, 2014-05, Vol.13 (5), p.1117-1129

2014

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Nature (London), 2016-06, Vol.534 (7605), p.129-132

2016

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Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

Science (American Association for the Advancement of Science), 2014-05, Vol.344 (6183), p.527-532

2014

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Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation

Molecules (Basel, Switzerland), 2021-05, Vol.26 (10), p.2847

2021

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Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

Cancer cell, 2015-01, Vol.27 (1), p.109-122

2015

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Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Cancer research (Chicago, Ill.), 2017-11, Vol.77 (22), p.6340-6352

2017

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Self-renewal as a therapeutic target in human colorectal cancer

Nature medicine, 2014-01, Vol.20 (1), p.29-36

2014

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

Nature communications, 2017-02, Vol.8 (1), p.14292-14292, Article 14292

2017

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Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery of luteolin: An in vivo/in vitro evaluation

International journal of pharmaceutics, 2016-10, Vol.512 (1), p.262-272

2016

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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Nature communications, 2017-02, Vol.8 (1), p.1-15, Article 14278

2017

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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

Cancer cell, 2017-10, Vol.32 (4), p.490-505.e10

2017

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IAP antagonists induce anti-tumor immunity in multiple myeloma

Nature medicine, 2016-12, Vol.22 (12), p.1411-1420

2016

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Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis

Bioorganic chemistry, 2019-04, Vol.85, p.253-273

2019

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Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

Cancer cell, 2013-07, Vol.24 (1), p.75-89

2013

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Synthesis and cytotoxicity evaluation of some novel thiazoles, thiadiazoles, and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones incorporating triazole moiety

Molecules (Basel, Switzerland), 2015-01, Vol.20 (1), p.1357-1376

2015

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Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

Clinical cancer research, 2011-09, Vol.17 (17), p.5546-5552

2011

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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Molecular cancer therapeutics, 2019-01, Vol.18 (1), p.3-16

2019

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Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling

Molecular cancer therapeutics, 2014-04, Vol.13 (4), p.855-866

2014

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Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp

Journal of the American Chemical Society, 2008-02, Vol.130 (6), p.1806-1807

2008

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Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

Molecules (Basel, Switzerland), 2018-05, Vol.23 (6), p.1318

2018

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

Thiazole-Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Self-renewal as a therapeutic target in human colorectal cancer

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

Vitamin E TPGS modified liposomes enhance cellular uptake and targeted delivery of luteolin: An in vivo/in vitro evaluation

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

IAP antagonists induce anti-tumor immunity in multiple myeloma

Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

Synthesis and cytotoxicity evaluation of some novel thiazoles, thiadiazoles, and pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones incorporating triazole moiety

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas

Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors

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