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Design, synthesis and biological evaluation of novel stilbene-based antitumor agents

Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.512-522

2009

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The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4373-4376

2008

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Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer

Bioorganic & medicinal chemistry, 2021-06, Vol.40, p.116129-116129, Article 116129

2021

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Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol

Bioorganic & medicinal chemistry, 2022-12, Vol.75, p.117072, Article 117072

2022

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Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs

Bioorganic & medicinal chemistry, 2020-11, Vol.28 (22), p.115710-115710, Article 115710

2020

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Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6770-6789

2012

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Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors

Bioorganic & medicinal chemistry, 2009-02, Vol.17 (4), p.1739-1746

2009

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Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (7), p.2397-2411

2005

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Diaryl naphthyl methanes a novel class of anti-implantation agents

Bioorganic & medicinal chemistry, 2004-03, Vol.12 (5), p.1011-1021

2004

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Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol- S-conjugate amidase by natural product inhibitors

Bioorganic & medicinal chemistry, 2003-02, Vol.11 (4), p.601-608

2003

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5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.2061-2073

2003

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11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Bioorganic & medicinal chemistry, 2004-02, Vol.12 (4), p.795-806

2004

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Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides

Bioorganic & medicinal chemistry, 2006-02, Vol.14 (4), p.997-1006

2006

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Structure-based drug design: Synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[b]oxepines as non-steroidal estrogens

Bioorganic & medicinal chemistry, 2003-11, Vol.11 (23), p.5025-5033

2003

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Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[ b]furan-3 a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition

Bioorganic & medicinal chemistry, 2004-06, Vol.12 (11), p.2903-2925

2004

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Synthesis and evaluation of cis-hexahydropyrrolo[3,2- b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

Bioorganic & medicinal chemistry, 2005-02, Vol.13 (3), p.609-625

2005

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5 -(3 -Cyclopentyl -2 -thioxo -2,3 -dihydro -1H -benzimidazol -5 -yl )-1-methyl -1H-pyrrole -2 -carbonitrile : A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist

Bioorganic & medicinal chemistry, 2007-10, Vol.15 (20), p.6556-6564

2007

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Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.2723-2739

2005

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Synthesis of hexahydrocyclopentimidazol-2-(1 H)-one derivatives displaying selective DP-receptor agonist properties

Bioorganic & medicinal chemistry, 1996, Vol.4 (1), p.81-90

1996

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Design, synthesis and biological evaluation of novel stilbene-based antitumor agents

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer

Bis-aryl-α,β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the cytosol

Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs

Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization

Design, synthesis, and anti-HIV activity of 4′-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors

Pyrazolopyridine antiherpetics: SAR of C2′ and C7 amine substituents

Diaryl naphthyl methanes a novel class of anti-implantation agents

Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol- S-conjugate amidase by natural product inhibitors

5H-dibenzo[c, h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

11H-isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides

Structure-based drug design: Synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[b]oxepines as non-steroidal estrogens

Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[ b]furan-3 a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition

Synthesis and evaluation of cis-hexahydropyrrolo[3,2- b]pyrrol-3-one peptidomimetic inhibitors of CAC1 cysteinyl proteinases

5 -(3 -Cyclopentyl -2 -thioxo -2,3 -dihydro -1H -benzimidazol -5 -yl )-1-methyl -1H-pyrrole -2 -carbonitrile : A novel, highly potent, selective, and orally active non-steroidal progesterone receptor agonist

Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

Synthesis of hexahydrocyclopentimidazol-2-(1 H)-one derivatives displaying selective DP-receptor agonist properties

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