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Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Biochimica et biophysica acta, 2014-05, Vol.1841 (5), p.766-772

Kihara, Akio

2014

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Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Journal of lipid research, 2020-06, Vol.61 (6), p.884-895

2020

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PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Nature communications, 2017-03, Vol.8 (1), p.14610-14610, Article 14610

2017

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Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

eLife, 2020-04, Vol.9

2020

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Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Journal of lipid research, 2024-06, Vol.65 (6), p.100550, Article 100550

2024

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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

The Journal of biological chemistry, 2016-04, Vol.291 (14), p.7477-7487

2016

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Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

Molecular and cellular biology, 2014-09, Vol.34 (18), p.3525-3534

2014

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Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

Journal of dermatological science, 2021-01, Vol.101 (1), p.69-71

2021

Volltextzugriff (PDF)

The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane

Biochemical journal, 2017-01, Vol.474 (1), p.51-63

2017

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Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Biochimica et biophysica acta, 2006-04, Vol.1761 (4), p.474-483

2006

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Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

Journal of dermatological science, 2022-08, Vol.107 (2), p.89-94

2022

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ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (43), p.18439-18444

2010

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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.263-271

2005

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Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

PloS one, 2014-07, Vol.9 (7), p.e101823-e101823

2014

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Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Biochemical and biophysical research communications, 2013-12, Vol.442 (3-4), p.195-201

2013

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N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane

Cell Structure and Function, 2020, Vol.45(1), pp.1-8

2020

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Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

The Journal of biological chemistry, 2012-11, Vol.287 (46), p.38473-38481

2012

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Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Journal of lipid research, 2014-03, Vol.55 (3), p.524-530

2014

Volltextzugriff (PDF)

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24736-24748

2014

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Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

Biochimica et biophysica acta, 2008-09, Vol.1781 (9), p.496-502

2008

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Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Journal of investigative dermatology, 2018-04, Vol.138 (4), p.741-749

2018

Volltextzugriff (PDF)

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

Molecular and Cellular Biology, 2013-07, Vol.33 (14), p.2787-2796

2013

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Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

Nature communications, 2014-10, Vol.5 (1), p.5338-5338, Article 5338

2014

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The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

The Journal of biological chemistry, 2017-09, Vol.292 (37), p.15538-15551

2017

Volltextzugriff (PDF)

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

Molecular biology of the cell, 2012-12, Vol.23 (23), p.4543-4551

2012

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1 – 25 von 206

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Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Signaling Events of the Rim101 Pathway Occur at the Plasma Membrane in a Ubiquitination-Dependent Manner

Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane

Membrane Protein Rim21 Plays a Central Role in Sensing Ambient pH in Saccharomyces cerevisiae

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

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