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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2175-2180

2009

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Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma

Blood, 2008-02, Vol.111 (3), p.1654-1664

2008

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A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells

Blood, 2011-05, Vol.117 (21), p.5692-5700

2011

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Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

British journal of haematology, 2010-05, Vol.149 (4), p.550-559

2010

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

Clinical cancer research, 2008-08, Vol.14 (16), p.5116-5123

2008

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Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis

Reproductive biology and endocrinology, 2012-12, Vol.10 (1), p.104-104

2012

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NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Clinical cancer research, 2006-11, Vol.12 (22), p.6758-6764

2006

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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MicroRNAs downregulated following immune activation of rat testis

American journal of reproductive immunology (1989), 2017-06, Vol.77 (6), p.n/a

2017

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Anti-TNF-α therapies: the next generation

Nature reviews. Drug discovery, 2003-09, Vol.2 (9), p.736-746

2003

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Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma

Blood, 2010-01, Vol.115 (4), p.834-845

2010

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Cancer cell, 2005-11, Vol.8 (5), p.407-419

2005

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Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes

Molecular pharmacology, 2007-06, Vol.71 (6), p.1545-1553

2007

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Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Investigational new drugs, 2012-12, Vol.30 (6), p.2303-2317

2012

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Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis

Basic and clinical andrology, 2018-11, Vol.28 (1), p.14-14, Article 14

2018

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Enantioselective Synthesis of the Antiinflammatory Agent (−)-Acanthoic Acid

Journal of organic chemistry, 2001-12, Vol.66 (26), p.8843-8853

2001

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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Blood, 2007-10, Vol.110 (7), p.2286-2295

2007

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Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-lndependent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

Clinical cancer research, 2008-08, Vol.14 (16), p.5116-5123

2008

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Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia

Blood, 2008-05, Vol.111 (9), p.4752-4763

2008

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Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa

American journal of reproductive immunology (1989), 2008-12, Vol.60 (6), p.541-555

2008

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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.479-486

2011

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Twenty-First-Century Spaces for Twenty-First-Century Learners: Where We Are, How We Got Here, and What Next

Council on Undergraduate Research quarterly, 2017-01, Vol.1 (2), p.12-17

2017

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Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Chemico-biological interactions, 2011-10, Vol.194 (1), p.58-68

2011

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Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

Planta medica, 2012-01, Vol.78 (2), p.131-134

2012

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Discovery and development of the anticancer agent salinosporamide A (NPI-0052)

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma

A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells

Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model

Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

MicroRNAs downregulated following immune activation of rat testis

Anti-TNF-α therapies: the next generation

Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis

Enantioselective Synthesis of the Antiinflammatory Agent (−)-Acanthoic Acid

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-lndependent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia

Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

Twenty-First-Century Spaces for Twenty-First-Century Learners: Where We Are, How We Got Here, and What Next

Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Trypanocidal activity of β-lactone-γ-lactam proteasome inhibitors

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