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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling

Journal of pharmaceutical sciences, 2022-01, Vol.111 (1), p.262-273

2022

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Perspective on a chemistry classification system for AI-assisted formulation development

Journal of controlled release, 2022-12, Vol.352, p.833-839

Bolger, Michael B.

2022

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

Advanced drug delivery reviews, 2001-10, Vol.50, p.S41-S67

2001

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Pharmaceutics, 2024-01, Vol.16 (1), p.96

2024

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Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.305-315

2019

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PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Pharmaceutics, 2021-08, Vol.13 (9), p.1325

2021

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Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

The AAPS journal, 2008, Vol.10 (1), p.213-226

2008

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In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Molecular pharmaceutics, 2012-03, Vol.9 (3), p.492-504

2012

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Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

The AAPS journal, 2009-06, Vol.11 (2), p.353-363

2009

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Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

The AAPS journal, 2009-06, Vol.11 (2), p.323-334

2009

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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

The AAPS journal, 2021-06, Vol.23 (4), p.89-89, Article 89

2021

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A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

European journal of pharmaceutical sciences, 2020-12, Vol.155, p.105552-105552, Article 105552

2020

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In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Pharmaceutical research, 2006-08, Vol.23 (8), p.1712-1720

2006

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Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

Drug metabolism and disposition, 2019-08, Vol.47 (8), p.818-831

2019

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The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Journal of pharmaceutical sciences, 2019-01, Vol.108 (1), p.268-278

2019

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Predicting the Effect of Fed-State Intestinal Contents on Drug Dissolution

Pharmaceutical research, 2010-12, Vol.27 (12), p.2646-2656

2010

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In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100899, Article 100899

2024

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Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

European journal of pharmaceutics and biopharmaceutics, 2020-10, Vol.155, p.55-68

2020

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The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1808-1818

2016

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Mutagenesis and Cysteine Scanning of Transmembrane Domain 10 of the Human Dipeptide Transporter

Pharmaceutical research, 2009-10, Vol.26 (10), p.2358-2366

2009

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Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

Pharmaceutical research, 2020-12, Vol.37 (12), p.245-245, Article 245

2020

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Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Journal of chemical education, 2020-08, Vol.97 (8), p.2212-2220

2020

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Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

Pharmaceutical research, 2020-06, Vol.37 (6), p.95-95, Article 95

2020

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PBPK models for the prediction of in vivo performance of oral dosage forms

Predicting Pharmacokinetics of Multisource Acyclovir Oral Products Through Physiologically Based Biopharmaceutics Modeling

Perspective on a chemistry classification system for AI-assisted formulation development

Predicting the impact of physiological and biochemical processes on oral drug bioavailability

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses

Application of a Dynamic Fluid and pH Model to Simulate Intraluminal and Systemic Concentrations of a Weak Base in GastroPlus

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

Application of Gastrointestinal Simulation for Extensions for Biowaivers of Highly Permeable Compounds

In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate

Simulations of the Nonlinear Dose Dependence for Substrates of Influx and Efflux Transporters in the Human Intestine

Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data

PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus

A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide

In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect

Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism

The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

Predicting the Effect of Fed-State Intestinal Contents on Drug Dissolution

In silico approach shows good predictability for free fraction in plasma and volume of distribution in human for drugs subjected to lysosomal trapping

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary

The Prediction of the Relative Importance of CYP3A/P-glycoprotein to the Nonlinear Intestinal Absorption of Drugs by Advanced Compartmental Absorption and Transit Model

Mutagenesis and Cysteine Scanning of Transmembrane Domain 10 of the Human Dipeptide Transporter

Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations

Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software

Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

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