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Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15725-15737

2022

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Cell chemical biology, 2020-01, Vol.27 (1), p.41-46.e17

2020

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Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

Cell chemical biology, 2020-01, Vol.27 (1), p.47-56.e15

2020

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PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer

Pharmacological research, 2024-07, Vol.205, p.107234, Article 107234

2024

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Proteome of the Large Pseudomonas Myovirus 201φ2-1: DELINEATION OF PROTEOLYTICALLY PROCESSED VIRION PROTEINS

Molecular & cellular proteomics, 2010-05, Vol.9 (5), p.940-951

2010

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PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Molecular cell, 2019-06, Vol.74 (6), p.1215-1226.e4

2019

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A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP

The EMBO journal, 2016-11, Vol.35 (21), p.2332-2349

2016

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IKZF2 Degradation: It's Time to Take into Account it When Designing Cereblon-Based PROTACs

Chembiochem : a European journal of chemical biology, 2024-08, Vol.25 (16), p.e202400365

Li, Minglei

2024

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Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance

European journal of medicinal chemistry, 2020-11, Vol.206, p.112689-112689, Article 112689

2020

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26S proteasome regulatory particle mutants have increased oxidative stress tolerance

The Plant journal : for cell and molecular biology, 2008-01, Vol.53 (1), p.102-114

2008

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Intramembrane proteolysis at a glance: from signalling to protein degradation

Journal of cell science, 2019-08, Vol.132 (16)

2019

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Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16355-16380

2024

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SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis

Developmental cell, 2017-04, Vol.41 (1), p.47-58.e4

2017

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Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

International journal of biological macromolecules, 2024-11, Vol.280 (Pt 2), p.135514, Article 135514

2024

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Discovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy

Journal of medicinal chemistry, 2023-06, Vol.66 (11), p.7454-7474

2023

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A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

Cell, 2018-01, Vol.172 (1-2), p.358-372.e23

2018

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A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

Theranostics, 2021-01, Vol.11 (11), p.5279-5295

2021

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The substrate repertoire of γ-secretase/presenilin

Seminars in cell & developmental biology, 2020-09, Vol.105, p.27-42

2020

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Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

EBioMedicine, 2018-10, Vol.36, p.553-562

2018

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A bibliometric analysis of PROTAC from 2001 to 2021

European journal of medicinal chemistry, 2022-12, Vol.244, p.114838-114838, Article 114838

2022

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Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.444-452

Churcher, Ian

2018

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Targeted protein degradation: A promise for undruggable proteins

Cell chemical biology, 2021-07, Vol.28 (7), p.934-951

2021

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PROTAC Technology: Opportunities and Challenges

ACS medicinal chemistry letters, 2020-03, Vol.11 (3), p.237-240

2020

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AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Molecular cell, 2019-12, Vol.76 (5), p.797-810.e10

2019

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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16712-16736

2024

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Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer

Proteome of the Large Pseudomonas Myovirus 201φ2-1: DELINEATION OF PROTEOLYTICALLY PROCESSED VIRION PROTEINS

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP

IKZF2 Degradation: It's Time to Take into Account it When Designing Cereblon-Based PROTACs

Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance

26S proteasome regulatory particle mutants have increased oxidative stress tolerance

Intramembrane proteolysis at a glance: from signalling to protein degradation

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis

Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

Discovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models

The substrate repertoire of γ-secretase/presenilin

Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs

A bibliometric analysis of PROTAC from 2001 to 2021

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

Targeted protein degradation: A promise for undruggable proteins

PROTAC Technology: Opportunities and Challenges

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

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