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Targeting cancer with small-molecule pan-KRAS degraders

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1338-1347

2024

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Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation

Biochimica et biophysica acta. Molecular cell research, 2024-10, Vol.1872 (1), p.119863, Article 119863

2024

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High resolution analysis of proteolytic substrate processing

The Journal of biological chemistry, 2024-09, Vol.300 (11), p.107812, Article 107812

2024

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EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Oncogene, 2024-08, Vol.43 (36), p.2722-2736

2024

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Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Journal of medical virology, 2024-09, Vol.96 (9), p.e29926-n/a

2024

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Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16355-16380

2024

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Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

International journal of biological macromolecules, 2024-11, Vol.280 (Pt 2), p.135514, Article 135514

2024

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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Journal of medicinal chemistry, 2024-09, Vol.67 (18), p.16712-16736

2024

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Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

The Journal of biological chemistry, 2024-11, Vol.300 (11), p.107842, Article 107842

2024

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Targeted nanoliposomes of oncogenic protein degraders: Significant inhibition of tumor in lung-cancer bearing mice

Journal of controlled release, 2024-12, Vol.376, p.502-517

2024

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KRAS takes the road to destruction

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.1274-1275

2024

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Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis

Journal of molecular biology, 2024-10, p.168837, Article 168837

2024

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A novel simple fluorometric protease assay for monitoring hydrolysis of proteins in real time

Analytical biochemistry, 2025-01, Vol.696, p.115688, Article 115688

2025

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Improvement of the production of pequi almond (Caryocar brasiliense Camb.) protein hydrolysates through ultrasound-assisted enzymolysis: Impact on hydrolysis kinetics, structure and functional properties of hydrolysates

Process biochemistry (1991), 2024-12, Vol.147, p.381-390

2024

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Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

PloS one, 2024-08, Vol.19 (8), p.e0309327

2024

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Impacts of Seasons and Regions on the Physicochemical, Microbiological and Sensory Characteristics of Kars Fresh Kashar Cheeses

International dairy journal, 2024-10, p.106120, Article 106120

2024

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Screen for temperature-sensitive mutants of non-essential yeast genes

Methods in enzymology, 2024, Vol.707, p.611-634

2024

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Nitric oxide action in the digestive fluid of Nepenthes × ventrata is linked to the modulation of ROS level

Plant physiology and biochemistry, 2024-11, Vol.216, p.109088, Article 109088

2024

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Exploring the oil-water interfacial behaviour of pea protein-guar gum/gellan gum mixtures relating to stability and in vitro protein digestion of model pea milk system

International journal of biological macromolecules, 2024-12, Vol.282 (Pt 1), p.136749, Article 136749

2024

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Synthesis, SAR, and application of JQ1 analogs as PROTACs for cancer therapy

Bioorganic & medicinal chemistry, 2024-10, Vol.112, p.117875, Article 117875

2024

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BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

Oncogene, 2024-09, Vol.43 (39), p.2914-2926

2024

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Differences in the growth, acidification, and proteolytic activities of Lactobacillus helveticus, Lactobacillus delbrueckii subsp. bulgaricus, and Streptococcus thermophilus in camel and cow milk fermentation

International dairy journal, 2025-01, Vol.160, p.106075, Article 106075

2025

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PROTAC as a novel anti-cancer strategy by targeting aging-related signaling

Seminars in cancer biology, 2024-11, Vol.106-107, p.143-155

2024

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PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

Scientific reports, 2024-09, Vol.14 (1), p.20824-16, Article 20824

2024

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A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1452

2024

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Targeting cancer with small-molecule pan-KRAS degraders

Interleukin-2 receptor α (IL-2Rα/CD25) shedding is differentially regulated by N- and O-glycosylation

High resolution analysis of proteolytic substrate processing

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs

Formation of thermal-induced microgels from soy protein hydrolysates: Effects of selective proteolysis on glycinin/β-conglycinin

Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis

Calpain-5 regulates muscle-specific protein expression and nuclear positioning during myoblast differentiation

Targeted nanoliposomes of oncogenic protein degraders: Significant inhibition of tumor in lung-cancer bearing mice

KRAS takes the road to destruction

Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis

A novel simple fluorometric protease assay for monitoring hydrolysis of proteins in real time

Improvement of the production of pequi almond (Caryocar brasiliense Camb.) protein hydrolysates through ultrasound-assisted enzymolysis: Impact on hydrolysis kinetics, structure and functional properties of hydrolysates

Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

Impacts of Seasons and Regions on the Physicochemical, Microbiological and Sensory Characteristics of Kars Fresh Kashar Cheeses

Screen for temperature-sensitive mutants of non-essential yeast genes

Nitric oxide action in the digestive fluid of Nepenthes × ventrata is linked to the modulation of ROS level

Exploring the oil-water interfacial behaviour of pea protein-guar gum/gellan gum mixtures relating to stability and in vitro protein digestion of model pea milk system

Synthesis, SAR, and application of JQ1 analogs as PROTACs for cancer therapy

BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

Differences in the growth, acidification, and proteolytic activities of Lactobacillus helveticus, Lactobacillus delbrueckii subsp. bulgaricus, and Streptococcus thermophilus in camel and cow milk fermentation

PROTAC as a novel anti-cancer strategy by targeting aging-related signaling

PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability

A Non-Canonical p75HER2 Signaling Pathway Underlying Trastuzumab Action and Resistance in Breast Cancer

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