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Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

Journal of the American Chemical Society, 2024-04, Vol.146 (15), p.10753-10766

2024

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New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Molecular cancer, 2024-05, Vol.23 (1), p.110-110

2024

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Dual-Capped Helical Interface Mimics

Journal of the American Chemical Society, 2024-04, Vol.146 (15), p.10331-10341

2024

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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Organic & biomolecular chemistry, 2024-05, Vol.22 (17), p.3477-3489

2024

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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7301-7311

2024

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Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

Nature communications, 2024-05, Vol.15 (1), p.4065-4065

2024

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In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

Chemico-biological interactions, 2024-05, Vol.395, p.111006-111006, Article 111006

2024

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Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.227-227

2024

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Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7283-7300

2024

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Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

PLoS biology, 2024-05, Vol.22 (5), p.e3002550-e3002550

2024

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Effects of Amino Acid Supplementation to a Low-Protein Diet on the Growth Performance and Protein Metabolism-related Factors in Broiler Chicks

The journal of poultry science, 2024-01, Vol.61, p.2024014-2024014

2024

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Correction: MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner

Cell death & disease, 2024-05, Vol.15 (5), p.320-320

2024

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Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1845

2024

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MMP-9-dependent proteolysis of the histone H3 N-terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis

Molecular oncology, 2024-04

2024

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Research progress of PROTACs for neurodegenerative diseases therapy

Bioorganic chemistry, 2024-06, Vol.147, p.107386-107386, Article 107386

2024

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Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): A Modular Platform for Generating Reversible, Self-Assembling Bifunctional Targeted Degraders

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5473-5501

2024

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PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis

BMC cancer, 2024-04, Vol.24 (1), p.504-504

2024

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Comparative assessment of radical scavenging potential of A1 and A2 cow's milk casein pre- and post-enzymatic hydrolysis

Food science & technology, 2024-04, Vol.198, Article 116038

2024

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Innovative, combinatorial and high-throughput approaches to degrader synthesis

Chemical Society reviews, 2024-05, Vol.53 (1), p.4838-4861

2024

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Ternary Complex‐Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo‐PROTACs

Angewandte Chemie International Edition, 2024-06, Vol.63 (25), p.e202319456-n/a

International ed. in English, 2024

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Lack of compensatory mitophagy in skeletal muscles during sepsis

The Journal of physiology, 2024-06, Vol.602 (12), p.2823-2838

2024

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A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

ACS chemical biology, 2024-05, Vol.19 (5), p.1161-1168

2024

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Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value

Breast cancer research and treatment, 2024-07, Vol.206 (1), p.143-153

2024

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Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

Bioorganic chemistry, 2024-06, Vol.147, p.107319-107319, Article 107319

2024

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SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

Bioorganic & medicinal chemistry, 2024-04, Vol.104, p.117699-117699, Article 117699

2024

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Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Dual-Capped Helical Interface Mimics

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

Effects of Amino Acid Supplementation to a Low-Protein Diet on the Growth Performance and Protein Metabolism-related Factors in Broiler Chicks

Correction: MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner

Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy

MMP-9-dependent proteolysis of the histone H3 N-terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis

Research progress of PROTACs for neurodegenerative diseases therapy

Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): A Modular Platform for Generating Reversible, Self-Assembling Bifunctional Targeted Degraders

PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis

Comparative assessment of radical scavenging potential of A1 and A2 cow's milk casein pre- and post-enzymatic hydrolysis

Innovative, combinatorial and high-throughput approaches to degrader synthesis

Ternary Complex‐Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo‐PROTACs

Lack of compensatory mitophagy in skeletal muscles during sepsis

A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

Expression of Cathepsin D in early-stage breast cancer and its prognostic and predictive value

Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

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