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Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation

Bioorganic & medicinal chemistry letters, 2024-07, Vol.107, p.129778-129778, Article 129778

2024

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Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

Journal of the American Chemical Society, 2024-04, Vol.146 (15), p.10753-10766

2024

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New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Molecular cancer, 2024-05, Vol.23 (1), p.110-110, Article 110

2024

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Dual-Capped Helical Interface Mimics

Journal of the American Chemical Society, 2024-04, Vol.146 (15), p.10331-10341

2024

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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Organic & biomolecular chemistry, 2024-05, Vol.22 (17), p.3477-3489

2024

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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7301-7311

2024

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Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

Nature communications, 2024-05, Vol.15 (1), p.4065-4065, Article 4065

2024

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In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

Chemico-biological interactions, 2024-05, Vol.395, p.111006-111006, Article 111006

2024

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Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Cellular and molecular life sciences : CMLS, 2024-12, Vol.81 (1), p.227-227, Article 227

2024

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Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7283-7300

2024

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Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

PLoS biology, 2024-05, Vol.22 (5), p.e3002550-e3002550

2024

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Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins

European journal of medicinal chemistry, 2024-06, Vol.272, p.116489-116489, Article 116489

2024

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Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1845

2024

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Research progress of PROTACs for neurodegenerative diseases therapy

Bioorganic chemistry, 2024-06, Vol.147, p.107386-107386, Article 107386

2024

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PROTAC induces HIV-1 Nef degradation

Nature reviews. Drug discovery, 2024-05, Vol.23 (5), p.340-340

Crunkhorn, Sarah

2024

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PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis

BMC cancer, 2024-04, Vol.24 (1), p.504-504, Article 504

2024

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Applications of protein ubiquitylation and deubiquitylation in drug discovery

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107264-107264, Article 107264

2024

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Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

The Journal of cell biology, 2024-08, Vol.223 (8)

2024

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Innovative, combinatorial and high-throughput approaches to degrader synthesis

Chemical Society reviews, 2024-05, Vol.53 (1), p.4838-4861

2024

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Synthetic protein circuits for programmable control of mammalian cell death

Cell, 2024-05, Vol.187 (11), p.2785-2800.e16

2024

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Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties

Cell, 2024-05, Vol.187 (11), p.2875-2892.e21

2024

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Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

Molecular cell, 2024-05, Vol.84 (9), p.1635-1636

Chen, Ruey-Hwa

2024

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A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

ACS chemical biology, 2024-05, Vol.19 (5), p.1161-1168

2024

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Small molecule induced STING degradation facilitated by the HECT ligase HERC4

Nature communications, 2024-05, Vol.15 (1), p.4584-16, Article 4584

2024

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Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

Bioorganic chemistry, 2024-06, Vol.147, p.107319-107319, Article 107319

2024

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Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation

Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs

New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

Dual-Capped Helical Interface Mimics

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Targeted protein degradation in mycobacteria uncovers antibacterial effects and potentiates antibiotic efficacy

In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins

Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy

Research progress of PROTACs for neurodegenerative diseases therapy

PROTAC induces HIV-1 Nef degradation

PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis

Applications of protein ubiquitylation and deubiquitylation in drug discovery

Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

Innovative, combinatorial and high-throughput approaches to degrader synthesis

Synthetic protein circuits for programmable control of mammalian cell death

Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties

Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis

A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

Small molecule induced STING degradation facilitated by the HECT ligase HERC4

Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

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