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Histopathological evidence that diethylene glycol produces kidney and nervous system damage in rats

Neurotoxicology (Park Forest South), 2022-07, Vol.91, p.200-210

2022

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The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation

Toxicology (Amsterdam), 2005-03, Vol.208 (3), p.347-355

2005

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Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells

Toxicological sciences, 2022-10, Vol.190 (1), p.1-12

2022

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Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol

Toxicology letters, 2023-04, Vol.379, p.48-55

2023

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Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation

Cardiovascular toxicology, 2020-12, Vol.20 (6), p.593-603

2020

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Diglycolic Acid Is the Nephrotoxic Metabolite in Diethylene Glycol Poisoning Inducing Necrosis in Human Proximal Tubule Cells In Vitro

Toxicological sciences, 2011-11, Vol.124 (1), p.35-44

2011

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Strain differences in urinary factors that promote calcium oxalate crystal formation in the kidneys of ethylene glycol-treated rats

American journal of physiology. Renal physiology, 2009-05, Vol.296 (5), p.F1080-F1087

2009

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Diglycolic acid inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death

Toxicology letters, 2013-08, Vol.221 (3), p.176-184

2013

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Human health assessment for long-term oral ingestion of diethylene glycol

Regulatory toxicology and pharmacology, 2017-06, Vol.87, p.S1-S20

2017

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Diethylene glycol-induced toxicities show marked threshold dose response in rats

Toxicology and applied pharmacology, 2015-02, Vol.282 (3), p.244-251

2015

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Aluminum Citrate Prevents Renal Injury from Calcium Oxalate Crystal Deposition

Journal of the American Society of Nephrology, 2012-12, Vol.23 (12), p.2024-2033

2012

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Role of Tissue Metabolite Accumulation in the Renal Toxicity of Diethylene Glycol

Toxicological sciences, 2011-10, Vol.123 (2), p.374-383

2011

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Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats

Toxicological sciences, 2010-09, Vol.117 (1), p.25-35

2010

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Calcium Oxalate Monohydrate, a Metabolite of Ethylene Glycol, Is Toxic for Rat Renal Mitochondrial Function

Toxicological sciences, 2005-03, Vol.84 (1), p.195-200

2005

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Involvement of urinary proteins in the rat strain difference in sensitivity to ethylene glycol-induced renal toxicity

American journal of physiology. Renal physiology, 2010-09, Vol.299 (3), p.F605-F615

2010

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Quantitation of Diethylene Glycol and Its Metabolites by Gas Chromatography Mass Spectrometry or Ion Chromatography Mass Spectrometry in Rat and Human Biological Samples

Journal of analytical toxicology, 2014-05, Vol.38 (4), p.184-193

2014

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Aluminum Citrate Blocks Toxicity of Calcium Oxalate Crystals by Preventing Binding with Cell Membrane Phospholipids

American journal of nephrology, 2013-01, Vol.37 (1), p.41-49

2013

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Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol

Toxicology letters, 2007-08, Vol.173 (1), p.8-16

2007

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Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect

Regulatory toxicology and pharmacology, 2013-03, Vol.65 (2), p.229-241

2013

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Relationship Between Serum Glycolate and Falsely Elevated Lactate in Severe Ethylene Glycol Poisoning

Journal of analytical toxicology, 2009-04, Vol.33 (3), p.174-176

2009

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Inhibition of NADPH oxidase activity promotes differentiation of B16 melanoma cells

Oncology reports, 2008-05, Vol.19 (5), p.1225-1230

2008

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Acute Ethanol Exposure Inhibits Renal Folate Transport, but Repeated Exposure Upregulates Folate Transport Proteins in Rats and Human Cells

The Journal of nutrition, 2007-05, Vol.137 (5), p.1260-1265

2007

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Aluminum citrate inhibits cytotoxicity and aggregation of oxalate crystals

Toxicology (Amsterdam), 2007-02, Vol.230 (2), p.117-125

2007

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Subchronic Toxicity of Ethylene Glycol in Wistar and F-344 Rats Related to Metabolism and Clearance of Metabolites

Toxicological sciences, 2004-10, Vol.81 (2), p.502-511

2004

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Aspartame: Review of Safety

Regulatory toxicology and pharmacology, 2002-04, Vol.35 (2), p.S1-S93

2002

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Histopathological evidence that diethylene glycol produces kidney and nervous system damage in rats

The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation

Role of Plasma Membrane Dicarboxylate Transporters in the Uptake and Toxicity of Diglycolic Acid, a Metabolite of Diethylene Glycol, in Human Proximal Tubule Cells

Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol

Calcium Oxalate Monohydrate is Associated with Endothelial Cell Toxicity But Not with Reactive Oxygen Species Accumulation

Diglycolic Acid Is the Nephrotoxic Metabolite in Diethylene Glycol Poisoning Inducing Necrosis in Human Proximal Tubule Cells In Vitro

Strain differences in urinary factors that promote calcium oxalate crystal formation in the kidneys of ethylene glycol-treated rats

Diglycolic acid inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death

Human health assessment for long-term oral ingestion of diethylene glycol

Diethylene glycol-induced toxicities show marked threshold dose response in rats

Aluminum Citrate Prevents Renal Injury from Calcium Oxalate Crystal Deposition

Role of Tissue Metabolite Accumulation in the Renal Toxicity of Diethylene Glycol

Inhibition of Metabolism of Diethylene Glycol Prevents Target Organ Toxicity in Rats

Calcium Oxalate Monohydrate, a Metabolite of Ethylene Glycol, Is Toxic for Rat Renal Mitochondrial Function

Involvement of urinary proteins in the rat strain difference in sensitivity to ethylene glycol-induced renal toxicity

Quantitation of Diethylene Glycol and Its Metabolites by Gas Chromatography Mass Spectrometry or Ion Chromatography Mass Spectrometry in Rat and Human Biological Samples

Aluminum Citrate Blocks Toxicity of Calcium Oxalate Crystals by Preventing Binding with Cell Membrane Phospholipids

Calcium oxalate, and not other metabolites, is responsible for the renal toxicity of ethylene glycol

Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect

Relationship Between Serum Glycolate and Falsely Elevated Lactate in Severe Ethylene Glycol Poisoning

Inhibition of NADPH oxidase activity promotes differentiation of B16 melanoma cells

Acute Ethanol Exposure Inhibits Renal Folate Transport, but Repeated Exposure Upregulates Folate Transport Proteins in Rats and Human Cells

Aluminum citrate inhibits cytotoxicity and aggregation of oxalate crystals

Subchronic Toxicity of Ethylene Glycol in Wistar and F-344 Rats Related to Metabolism and Clearance of Metabolites

Aspartame: Review of Safety

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