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Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

Nature reviews. Drug discovery, 2010-08, Vol.9 (8), p.628-642

2010

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The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders

The Journal of neuroscience, 2014-02, Vol.34 (6), p.2015-2024

2014

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Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

Biological psychiatry (1969), 2006-06, Vol.59 (11), p.1087-1096

2006

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Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats

Psychopharmacologia, 2011-10, Vol.217 (3), p.301-313

2011

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Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Scientific reports, 2017-04, Vol.8 (1), p.45907, Article 45907

2017

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Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

Neuropsychopharmacology, 2009-10, Vol.34 (11), p.2390-2403

2009

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Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat

Neuropsychopharmacology, 2003-04, Vol.28 (4), p.694-703

2003

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Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

Journal of psychiatry & neuroscience, 2004-03, Vol.29 (2), p.126-133

2004

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Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence

Pain (Amsterdam), 2017-01, Vol.158 (1), p.149-160

2017

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Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

Psychopharmacologia, 2012-06, Vol.221 (3), p.493-509

2012

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S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

Frontiers in pharmacology, 2017-07, Vol.8, p.462-462

2017

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Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety

Behavioural pharmacology, 2006-02, Vol.17 (1), p.9

2006

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Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

Behavioural brain research, 2011-03, Vol.218 (1), p.121-128

2011

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Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat

Pharmacology, biochemistry and behavior, 2011-06, Vol.98 (4), p.511-517

2011

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Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

The international journal of neuropsychopharmacology, 2012-04, Vol.15 (3), p.321-335

2012

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Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice

The international journal of neuropsychopharmacology, 2010-07, Vol.13 (6), p.759-774

2010

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Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors

Life sciences (1973), 2016-06, Vol.155, p.147-154

2016

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Retraction Note: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Alzheimer's research & therapy, 2022-06, Vol.14 (1), p.1-76, Article 76

2022

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The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala

Brain research, 2012-07, Vol.1466, p.91-98

2012

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Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice

Journal of neurochemistry, 2012-12, Vol.123 (5), p.811-823

2012

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Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

The international journal of neuropsychopharmacology, 2013-03, Vol.16 (2), p.323-338

2013

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S33138 [ N -[4-[2-[(3 aS ,9 bR )-8-Cyano-1,3 a ,4,9 b -tetrahydro[1]-benzopyrano[3,4- c ]pyrrol-2(3 H )-yl)-ethyl]phenylacetamide], a Preferential Dopamine D 3 versus D 2 Receptor Antagonist and Potential Antipsychotic Agent. II. A Neurochemical, Electrophysiological and Behavioral Characterization in Vivo

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.600-611

2008

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Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression

Pharmacology, biochemistry and behavior, 2011-12, Vol.100 (2), p.284-288

2011

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Antidepressant action of agomelatine (S 20098) in a transgenic mouse model

Progress in neuro-psychopharmacology & biological psychiatry, 2005-07, Vol.29 (6), p.908-916

2005

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Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain

Journal of neuroscience research, 2011-10, Vol.89 (10), p.1646-1657

2011

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Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders

Agomelatine, a New Antidepressant, Induces Regional Changes in Hippocampal Neurogenesis

Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence

Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms

Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety

Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice

Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors

Retraction Note: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala

Pharmacological or genetic blockade of the dopamine D3 receptor increases cell proliferation in the hippocampus of adult mice

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression

Antidepressant action of agomelatine (S 20098) in a transgenic mouse model

Chronic stress and antidepressant agomelatine induce region-specific changes in synapsin I expression in the rat brain

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