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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

The Journal of physiology, 2020-05, Vol.598 (9), p.1683-1693

Colecraft, Henry M.

2020

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Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Nature (London), 2020-01, Vol.577 (7792), p.695-700

2020

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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

PloS one, 2016-01, Vol.11 (1), p.e0145750-e0145750

2016

Volltextzugriff (PDF)

Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect

Nature medicine, 2016-10, Vol.22 (10), p.1170-1179

2016

Volltextzugriff (PDF)

Structure and selectivity in bestrophin ion channels

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6207), p.355-359

2014

Volltextzugriff (PDF)

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

PloS one, 2012-05, Vol.7 (5), p.e37079-e37079

2012

Volltextzugriff (PDF)

Structural mechanism of ligand activation in human calcium-sensing receptor

eLife, 2016-07, Vol.5 (2016)

2016

Volltextzugriff (PDF)

Potassium channels in the heart: structure, function and regulation

The Journal of physiology, 2017-04, Vol.595 (7), p.2209-2228

2017

Volltextzugriff (PDF)

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

Heart rhythm, 2016-08, Vol.13 (8), p.1699-1706

2016

Volltextzugriff (PDF)

High-fat diet-dependent modulation of the delayed rectifier K+ current in adult guinea pig atrial myocytes

Biochemical and biophysical research communications, 2016-06, Vol.474 (3), p.554-559

2016

Volltextzugriff (PDF)

Sculpting ion channel functional expression with engineered ubiquitin ligases

eLife, 2017-12, Vol.6

2017

Volltextzugriff (PDF)

BIN1 localizes the L-type calcium channel to cardiac T-tubules

PLoS biology, 2010-02, Vol.8 (2), p.e1000312-e1000312

2010

Volltextzugriff (PDF)

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

eLife, 2019-08, Vol.8

2019

Volltextzugriff (PDF)

Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18213-18218

2014

Volltextzugriff (PDF)

Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Circulation (New York, N.Y.), 2018-10, Vol.138 (14), p.1431-1445

2018

Volltextzugriff (PDF)

Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Nature communications, 2022-12, Vol.13 (1), p.7556-7556, Article 7556

2022

Volltextzugriff (PDF)

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Frontiers in physiology, 2018-04, Vol.9, p.397-397

2018

Volltextzugriff (PDF)

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Molecular therapy. Nucleic acids, 2023-12, Vol.34, p.102032-102032, Article 102032

2023

Volltextzugriff (PDF)

A light-gated potassium channel for sustained neuronal inhibition

Nature methods, 2018-11, Vol.15 (11), p.969

2018

Volltextzugriff (PDF)

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

eLife, 2023-08, Vol.12

2023

Volltextzugriff (PDF)

Ion channels: channel production and optical methods

2021

Volltextzugriff (PDF)

Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

Cell death & disease, 2023-04, Vol.14 (4), p.297-297, Article 297

2023

Volltextzugriff (PDF)

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Cardiovascular research, 2014-12, Vol.104 (3), p.501-511

2014

Volltextzugriff (PDF)

Ion channels: channel chemical biology, engineering, and physiological function

2021

Volltextzugriff (PDF)

Research Highlights: Biophysics of Calcium

Biophysical journal, 2020-10, Vol.119 (8), p.1472-1473

Colecraft, Henry M.

2020

Volltextzugriff (PDF)

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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect

Structure and selectivity in bestrophin ion channels

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

Structural mechanism of ligand activation in human calcium-sensing receptor

Potassium channels in the heart: structure, function and regulation

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

High-fat diet-dependent modulation of the delayed rectifier K+ current in adult guinea pig atrial myocytes

Sculpting ion channel functional expression with engineered ubiquitin ligases

BIN1 localizes the L-type calcium channel to cardiac T-tubules

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

A light-gated potassium channel for sustained neuronal inhibition

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

Ion channels: channel production and optical methods

Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Ion channels: channel chemical biology, engineering, and physiological function

Research Highlights: Biophysics of Calcium

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