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High-Throughput Virtual Screening Identifies Novel N′‑(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9496-9508

2013

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Targeting Axl and Mer kinases in cancer

Molecular cancer therapeutics, 2011-10, Vol.10 (10), p.1763-1773

2011

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

Proceedings of the National Academy of Sciences - PNAS, 2002-09, Vol.99 (18), p.11593-11598

2002

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A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

Neoplasia (New York, N.Y.), 2014-05, Vol.16 (5), p.403-412

2014

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S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

Molecular cancer therapeutics, 2010-05, Vol.9 (5), p.1443-1450

2010

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Nature communications, 2021-09, Vol.12 (1), p.5337-5337, Article 5337

2021

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Use of a bacteriophage lysin to identify a novel target for antimicrobial development

PloS one, 2013-04, Vol.8 (4), p.e60754-e60754

2013

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TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Cancer research (Chicago, Ill.), 2013-11, Vol.73 (21), p.6516-6525

2013

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Upregulation of AXL and β-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance

Blood cancer journal (New York), 2021-02, Vol.11 (2), p.37-37, Article 37

2021

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Telomere inhibition and telomere disruption as processes for drug targeting

Annual review of pharmacology and toxicology, 2003-01, Vol.43 (1), p.359-379

2003

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Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis

The Journal of biological chemistry, 2013-01, Vol.288 (4), p.2261-2270

2013

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Are Accurins the cure for Aurora kinase inhibitors?

Science translational medicine, 2016-02, Vol.8 (325), p.325fs4

Bearss, David J

2016

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Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

Molecular cancer therapeutics, 2006-07, Vol.5 (7), p.1764-1773

2006

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Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer

Molecular cancer therapeutics, 2004-05, Vol.3 (5), p.641-646

2004

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Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

Clinical cancer research, 2015-05, Vol.21 (9), p.2115-2126

2015

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Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Cancer research (Chicago, Ill.), 2020-04, Vol.80 (7), p.1551-1563

2020

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Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (24), p.5473-5480

2017

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The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

Molecular cancer therapeutics, 2004-04, Vol.3 (4), p.451-457

2004

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Mutations in the G-Quadruplex Silencer Element and Their Relationship to c-MYC Overexpression, NM23 Repression, and Therapeutic Rescue

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (16), p.6140-6145

2004

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Shining the light on aurora-a kinase as a drug target in pancreatic cancer

Molecular cancer therapeutics, 2011-11, Vol.10 (11), p.2012-2012

Bearss, David J

2011

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Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors

ACS medicinal chemistry letters, 2011-12, Vol.2 (12), p.907-912

2011

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Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (10), p.2890-2896

2002

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The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo

Molecular cancer therapeutics, 2002-06, Vol.1 (8), p.565-573

2002

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Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy

Oncotarget, 2018-12, Vol.9 (98), p.37173-37184

2018

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An Epithelial―Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

High-Throughput Virtual Screening Identifies Novel N′‑(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors

Targeting Axl and Mer kinases in cancer

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Use of a bacteriophage lysin to identify a novel target for antimicrobial development

TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase

Upregulation of AXL and β-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance

Telomere inhibition and telomere disruption as processes for drug targeting

Chemical Genetic Screen Reveals a Role for Desmosomal Adhesion in Mammary Branching Morphogenesis

Are Accurins the cure for Aurora kinase inhibitors?

Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach

Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer

Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors

The mitotic serine threonine kinase, Aurora-2, is a potential target for drug development in human pancreatic cancer

Mutations in the G-Quadruplex Silencer Element and Their Relationship to c-MYC Overexpression, NM23 Repression, and Therapeutic Rescue

Shining the light on aurora-a kinase as a drug target in pancreatic cancer

Design, Synthesis, and Biological Evaluation of a Series of Novel AXL Kinase Inhibitors

Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray

The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo

Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy

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