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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Neuron (Cambridge, Mass.), 2016-05, Vol.90 (3), p.507-520

2016

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Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Neuron (Cambridge, Mass.), 2009-12, Vol.64 (6), p.828-840

2009

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Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

The Journal of neuroscience, 2008-11, Vol.28 (45), p.11500-11510

2008

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Human molecular genetics, 2008-12, Vol.17 (23), p.3767-3775

2008

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SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

Cell reports (Cambridge), 2013-07, Vol.4 (2), p.362-375

2013

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8914

2021

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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A cause for childhood ataxia

eLife, 2016-03, Vol.5

Steffan, Joan S

2016

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The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

Human molecular genetics, 2007-01, Vol.16 (1), p.61-77

2007

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Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Experimental neurology, 2021-04, Vol.338, p.113463, Article 113463

2021

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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

Journal of cell science, 2022-01, Vol.135 (2)

2022

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

The Journal of cell biology, 2009-12, Vol.187 (7), p.1083-1099

2009

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Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29427-29436

2009

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Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Journal of Huntington's disease, 2022-01, Vol.11 (1), p.25

2022

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Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Stem cells translational medicine, 2017-06, Vol.6 (6), p.1477-1490

2017

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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

Journal of Huntington's disease, 2018-01, Vol.7 (2), p.137

2018

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Nature genetics, 2002-04, Vol.30 (4), p.367-376

2002

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Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

Journal of Huntington's disease, 2018-01, Vol.7 (4), p.321

2018

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Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

Journal of Huntington's disease, 2012, Vol.1 (1), p.71

2012

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RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I

The Journal of biological chemistry, 1996-08, Vol.271 (35), p.21062-21067

1996

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Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae

Biochemistry (Easton), 1988-11, Vol.27 (22), p.8393-8400

1988

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Expression and Function of a Mislocalized Form of Peroxisomal Malate Dehydrogenase (MDH3) in Yeast (∗)

The Journal of biological chemistry, 1995-09, Vol.270 (36), p.21220-21225

1995

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The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor

Genes & development, 1996-10, Vol.10 (20), p.2551-2563

1996

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Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase

The Journal of biological chemistry, 1992-12, Vol.267 (34), p.24708-24715

1992

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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

A cause for childhood ataxia

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY

Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I

Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae

Expression and Function of a Mislocalized Form of Peroxisomal Malate Dehydrogenase (MDH3) in Yeast (∗)

The role of TBP in rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae: TBP is required for upstream activation factor-dependent recruitment of core factor

Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase

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