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Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α 2 -macroglobulin

Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (19), p.e2200102119

2022

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Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.E4587-E4595

2014

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Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

Science (American Association for the Advancement of Science), 2005-03, Vol.307 (5715), p.1630-1634

2005

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Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.8290-8295

2015

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DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

The Journal of cell biology, 2007-02, Vol.176 (4), p.445-458

2007

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The Human Silent Information Regulator (Sir)2 Homologue hSIRT3 Is a Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase

The Journal of cell biology, 2002-08, Vol.158 (4), p.647-657

2002

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The F-Box Protein AhSLF-S₂ Physically Interacts with S-RNases That May Be Inhibited by the Ubiquitin/26S Proteasome Pathway of Protein Degradation during Compatible Pollination in Antirrhinum

The Plant cell, 2004-03, Vol.16 (3), p.582-595

2004

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The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (18), p.10410-10415

2001

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Physical Association of Ubiquitin Ligases and the 26S Proteasome

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (6), p.2497-2502

2000

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HA95 and LAP2β Mediate a Novel Chromatin-Nuclear Envelope Interaction Implicated in Initiation of DNA Replication

The Journal of cell biology, 2003-01, Vol.160 (2), p.177-188

2003

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Regulation of lck Degradation and Refractory State in CD8+Cytotoxic T Lymphocytes

Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (26), p.9264-9269

2005

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Medicine. How thalidomide works against cancer

Science (American Association for the Advancement of Science), 2014-01, Vol.343 (6168), p.256

Stewart, A Keith

2014

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DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

Science (American Association for the Advancement of Science), 2015-06, Vol.348 (6241), p.1376-1381

2015

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Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (8), p.2933-2938

2007

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Molecular biology. New proteases in a ubiquitin stew

Science (American Association for the Advancement of Science), 2002-10, Vol.298 (5593), p.549-552

Hochstrasser, Mark

2002

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Two Types of Human Mast Cells That Have Distinct Neutral Protease Compositions

Proceedings of the National Academy of Sciences - PNAS, 1986-06, Vol.83 (12), p.4464-4468

1986

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Survey of Amino-Terminal Proteolytic Cleavage Sites in Mitochondrial Precursor Proteins: Leader Peptides Cleaved by Two Matrix Proteases Share a Three-Amino Acid Motif

Proceedings of the National Academy of Sciences - PNAS, 1989-06, Vol.86 (11), p.4056-4060

1989

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Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (11), p.4316

2011

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Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex

The Journal of cell biology, 2000-07, Vol.150 (1), p.53-64

2000

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The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

Proceedings of the National Academy of Sciences - PNAS, 2003-03, Vol.100 (6), p.3239

2003

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Two Mitochondrial Matrix Proteases Act Sequentially in the Processing of Mammalian Matrix Enzymes

Proceedings of the National Academy of Sciences - PNAS, 1988-10, Vol.85 (20), p.7536-7540

1988

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Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

Proceedings of the National Academy of Sciences - PNAS, 1980-04, Vol.77 (4), p.1783-1786

1980

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Autodigestion of lexA and Phage λ Repressors

Proceedings of the National Academy of Sciences - PNAS, 1984-03, Vol.81 (5), p.1375-1379

Little, John W.

1984

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Plant sciences. Recognition at a distance

Science (American Association for the Advancement of Science), 2005-04, Vol.308 (5721), p.506-508

2005

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Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities

Proceedings of the National Academy of Sciences - PNAS, 1991-03, Vol.88 (6), p.2194-2198

1991

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Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α 2 -macroglobulin

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

The Human Silent Information Regulator (Sir)2 Homologue hSIRT3 Is a Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase

The F-Box Protein AhSLF-S₂ Physically Interacts with S-RNases That May Be Inhibited by the Ubiquitin/26S Proteasome Pathway of Protein Degradation during Compatible Pollination in Antirrhinum

The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

Physical Association of Ubiquitin Ligases and the 26S Proteasome

HA95 and LAP2β Mediate a Novel Chromatin-Nuclear Envelope Interaction Implicated in Initiation of DNA Replication

Regulation of lck Degradation and Refractory State in CD8+Cytotoxic T Lymphocytes

Medicine. How thalidomide works against cancer

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia

Molecular biology. New proteases in a ubiquitin stew

Two Types of Human Mast Cells That Have Distinct Neutral Protease Compositions

Survey of Amino-Terminal Proteolytic Cleavage Sites in Mitochondrial Precursor Proteins: Leader Peptides Cleaved by Two Matrix Proteases Share a Three-Amino Acid Motif

Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51

Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

Two Mitochondrial Matrix Proteases Act Sequentially in the Processing of Mammalian Matrix Enzymes

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

Autodigestion of lexA and Phage λ Repressors

Plant sciences. Recognition at a distance

Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities

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