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Analysis of exposure margins in developmental toxicity studies for detection of human teratogens

Regulatory toxicology and pharmacology, 2019-07, Vol.105, p.62-68

2019

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A Brief History of Use of Animals in Biomedical Research and Perspective on Non-Animal Alternatives

ILAR journal, 2021-12, Vol.62 (1-2), p.7-16

2021

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Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection

Regulatory toxicology and pharmacology, 2019-10, Vol.107, p.104413, Article 104413

2019

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Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Hepatology (Baltimore, Md.), 2016-11, Vol.64 (5), p.1430-1441

2016

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Regulatory Forum Commentary Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies

Toxicologic pathology, 2015-07, Vol.43 (5), p.621-627

2015

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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.107-114

2016

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Use of Alternative Developmental Toxicity Assays to Assess Teratogenicity Potential of Pharmaceuticals

Applied in vitro toxicology, 2018-03, Vol.4 (1), p.44-53

2018

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An Industry Perspective on the Utility of Short-Term Carcinogen- icity Testing in Transgenic Mice in Pharmaceutical Development

Toxicologic pathology, 2010, Vol.38 (1), p.51-61

2010

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Regulatory considerations for preclinical development of anticancer drugs

Cancer chemotherapy and pharmacology, 1997-12, Vol.41 (3), p.173-185

1997

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In Vivo Transgenic Bioassays and Assessment of the Carcinogenic Potential of Pharmaceuticals

Environmental health perspectives, 1998-02, Vol.106, p.71

1998

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The duration of non-rodent toxicity studies for pharmaceuticals

Toxicological sciences, 1999-06, Vol.49 (2), p.143-155

1999

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Arecoline‐Stimulated Brain Incorporation of Intravenously Administered Fatty Acids in Unanesthetized Rats

Journal of neurochemistry, 1991-01, Vol.56 (1), p.352-355

1991

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ICI 182,780 inhibits endogenous estrogen-dependent rat uterine growth and tamoxifen-induced developmental toxicity

Biology of reproduction, 1996-01, Vol.54 (1), p.160-167

1996

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Effects of pentobarbital on incorporation of plasma palmitate into rat brain

Anesthesiology (Philadelphia), 1994, Vol.80 (1), p.151-158

1994

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In vivo brain incorporation of [1- 14C]arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of nucleus basalis magnocellularis

Brain research, 1991-09, Vol.559 (1), p.1-9

1991

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Differences in rates of incorporation of intravenously injected radiolabeled fatty acids into phospholipids of intracerebrally implanted tumor and brain in awake rats

Clinical & experimental metastasis, 1994-05, Vol.12 (3), p.213-225

1994

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In vivo incorporation of [9,10(-3)H]-palmitate into a rat metastatic brain-tumor model

Journal of neurosurgery, 1991-04, Vol.74 (4), p.643-649

1991

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Intravenously injected radiolabelled fatty acids image brain tumour phospholipids in vivo: differential uptakes of palmitate, arachidonate and docosahexaenoate

Clinical & experimental metastasis, 1993-03, Vol.11 (2), p.141-149

1993

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Synthesis of a fluorinated fatty acid, dl-erythro-9,10-[ 18F]difluoropalmitic acid, and biodistribution studies in rats

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1990, Vol.17 (8), p.805-809

1990

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Importance of Halogen···Halogen Contacts for the Structural and Magnetic Properties of CuX 2 (pyrazine- N , N ′-dioxide)(H 2 O) 2 (X = Cl and Br)

Inorganic chemistry, 2012-02, Vol.51 (4), p.2121-2129

2012

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Importance of Halogen···Halogen Contacts for the Structural and Magnetic Properties of CuX2(pyrazine-N,N′-dioxide)(H2O)2 (X = Cl and Br)

Inorganic chemistry, 2012-02, Vol.51 (4), p.2121-2129

2012

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Atlas of Operative Craniofacial Surgery

John Mesa, Steven R. Buchman, Donald R. Mackay, Joseph E. Losee, Robert J. Havlik, John Mesa, Steven R. Buchman, Donald R. MacKay

1, 2019

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Cardiac-Restricted Overexpression of the A2A-Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A1-Adenosine Receptor

Clinical and translational science, 2008-09, Vol.1 (2), p.126-133

2008

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Atlas of Operative Craniofacial Surgery

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Cardiac‐Restricted Overexpression of the A 2A ‐Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A 1 ‐Adenosine Receptor

Clinical and translational science, 2008-09, Vol.1 (2), p.126-133

2008

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Analysis of exposure margins in developmental toxicity studies for detection of human teratogens

A Brief History of Use of Animals in Biomedical Research and Perspective on Non-Animal Alternatives

Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection

Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Regulatory Forum Commentary Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies

Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs

Use of Alternative Developmental Toxicity Assays to Assess Teratogenicity Potential of Pharmaceuticals

An Industry Perspective on the Utility of Short-Term Carcinogen- icity Testing in Transgenic Mice in Pharmaceutical Development

Regulatory considerations for preclinical development of anticancer drugs

In Vivo Transgenic Bioassays and Assessment of the Carcinogenic Potential of Pharmaceuticals

The duration of non-rodent toxicity studies for pharmaceuticals

Arecoline‐Stimulated Brain Incorporation of Intravenously Administered Fatty Acids in Unanesthetized Rats

ICI 182,780 inhibits endogenous estrogen-dependent rat uterine growth and tamoxifen-induced developmental toxicity

Effects of pentobarbital on incorporation of plasma palmitate into rat brain

In vivo brain incorporation of [1- 14C]arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of nucleus basalis magnocellularis

Differences in rates of incorporation of intravenously injected radiolabeled fatty acids into phospholipids of intracerebrally implanted tumor and brain in awake rats

In vivo incorporation of [9,10(-3)H]-palmitate into a rat metastatic brain-tumor model

Intravenously injected radiolabelled fatty acids image brain tumour phospholipids in vivo: differential uptakes of palmitate, arachidonate and docosahexaenoate

Synthesis of a fluorinated fatty acid, dl-erythro-9,10-[ 18F]difluoropalmitic acid, and biodistribution studies in rats

Importance of Halogen···Halogen Contacts for the Structural and Magnetic Properties of CuX 2 (pyrazine- N , N ′-dioxide)(H 2 O) 2 (X = Cl and Br)

Importance of Halogen···Halogen Contacts for the Structural and Magnetic Properties of CuX2(pyrazine-N,N′-dioxide)(H2O)2 (X = Cl and Br)

Atlas of Operative Craniofacial Surgery

Cardiac-Restricted Overexpression of the A2A-Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A1-Adenosine Receptor

Atlas of Operative Craniofacial Surgery

Cardiac‐Restricted Overexpression of the A 2A ‐Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A 1 ‐Adenosine Receptor

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