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Aconitum and Delphinium alkaloids of curare-like activity. QSAR analysis and molecular docking of alkaloids into AChBP

European journal of medicinal chemistry, 2010-09, Vol.45 (9), p.3885-3894

2010

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3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3108-3112

2009

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Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (8), p.2675-2678

2008

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An efficient approach to the asymmetric total synthesis of (–)-anisodine

European journal of medicinal chemistry, 2006-03, Vol.41 (3), p.397-400

2006

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Alzheimer's disease: emerging trends in small molecule therapies

Current medicinal chemistry, 2011-10, Vol.18 (28), p.4299

2011

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The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine

Current medicinal chemistry, 2009-11, Vol.16 (33), p.4481

2009

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Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4705-4745

2005

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Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1354-1358

2011

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Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.88-91

2011

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Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (20), p.6107-6119

2011

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Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2476-2479

2011

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Anticholinergic effects of oral antipsychotic drugs of typicals versus atypicals over medium- and long-term: systematic review and meta-analysis

Current medicinal chemistry, 2012-10, Vol.19 (30), p.5214

2012

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QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release

Bioorganic & medicinal chemistry, 2006-05, Vol.14 (9), p.3017-3037

2006

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Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4169-4194

1997

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Interaction of nerve agent antidotes with cholinergic systems

Current medicinal chemistry, 2010-06, Vol.17 (16), p.1708

2010

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Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride ( 8018)

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1979-1982

2005

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Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase

Bioorganic & medicinal chemistry, 2010-01, Vol.18 (2), p.787-794

2010

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Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5575-5584

2008

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Synthesis, Structure Elucidation, in Vitro Biological Activity, Toxicity, and Caco-2 Cell Permeability of Lipophilic Analogues of α-Conotoxin MII

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1266-1272

2003

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Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

European journal of medicinal chemistry, 2011-02, Vol.46 (2), p.811-818

2011

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Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.885-890

2008

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Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4333-4353

2000

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First Gallamine−Tacrine Hybrid: Design and Characterization at Cholinesterases and the M2 Muscarinic Receptor

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5685-5695

2007

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Effect of nicotine on the proliferation and differentiation of mouse induced pluripotent stem cells

Current medicinal chemistry, 2012-10, Vol.19 (30), p.5164

2012

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Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4560-4562

2009

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Aconitum and Delphinium alkaloids of curare-like activity. QSAR analysis and molecular docking of alkaloids into AChBP

3D-QSAR study of 8-azabicyclo[3.2.1] octane analogs antagonists of cholinergic receptor

Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD

An efficient approach to the asymmetric total synthesis of (–)-anisodine

Alzheimer's disease: emerging trends in small molecule therapies

The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine

Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain

Anticholinergic effects of oral antipsychotic drugs of typicals versus atypicals over medium- and long-term: systematic review and meta-analysis

QSAR modeling of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating dopamine release

Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery

Interaction of nerve agent antidotes with cholinergic systems

Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride ( 8018)

Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase

Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

Synthesis, Structure Elucidation, in Vitro Biological Activity, Toxicity, and Caco-2 Cell Permeability of Lipophilic Analogues of α-Conotoxin MII

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists

Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System

First Gallamine−Tacrine Hybrid: Design and Characterization at Cholinesterases and the M2 Muscarinic Receptor

Effect of nicotine on the proliferation and differentiation of mouse induced pluripotent stem cells

Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

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