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Dysregulation of the TSC-mTOR pathway in human disease

Nature genetics, 2005-01, Vol.37 (1), p.19-24

2005

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Biallelic TSC gene inactivation in tuberous sclerosis complex

Neurology, 2010-05, Vol.74 (21), p.1716

2010

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Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

Human molecular genetics, 2010-02, Vol.19 (3), p.397-410

2010

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The long and winding road to rational treatment of cancer associated with LKB1 AMPK TSC mTORC1 signaling

Oncogene, 2011-05, Vol.30 (20), p.2289-2303

2011

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Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway

CNS neuroscience & therapeutics, 2012-07, Vol.18 (7), p.536-546

2012

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Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

Human molecular genetics, 2009-06, Vol.18 (12), p.2166-2176

2009

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A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity

British journal of dermatology (1951), 2011-10, Vol.165 (4), p.912-916

2011

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Insulin signaling pathways in cortical dysplasia and TSC-tubers: Tissue microarray analysis

Annals of neurology, 2004-10, Vol.56 (4), p.510-519

2004

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Clinical features distinguish childhood chordoma associated with tuberous sclerosis complex (TSC) from chordoma in the general paediatric population

Journal of medical genetics, 2011-07, Vol.48 (7), p.444-449

2011

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Survey of Somatic Mutations in Tuberous Sclerosis Complex (TSC) Hamartomas Suggests Different Genetic Mechanisms for Pathogenesis of TSC Lesions

American journal of human genetics, 2001-09, Vol.69 (3), p.493-503

2001

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Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC‐cortical tubers

Epilepsia (Copenhagen), 2009-06, Vol.50 (6), p.1409-1418

2009

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Focal cortical dysplasia: A genotype–phenotype analysis of polymorphisms and mutations in the TSC genes

Epilepsia (Copenhagen), 2009-06, Vol.50 (6), p.1396-1408

2009

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Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genes

European journal of cancer (1990), 2005-07, Vol.41 (11), p.1628-1636

2005

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Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features

Human molecular genetics, 2012-10, Vol.21 (19), p.4286-4300

2012

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Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress

Placenta (Eastbourne), 2011-06, Vol.32 (6), p.475-481

2011

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Neuropsychological attention deficits in tuberous sclerosis complex (TSC)

American journal of medical genetics. Part A, 2009-03, Vol.149A (3), p.387-395

2009

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Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells

Oncogene, 2002-06, Vol.21 (25), p.4050-4059

2002

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Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

Oncogene, 2003-07, Vol.22 (31), p.4786-4798

2003

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Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology

Glia, 2004-04, Vol.46 (1), p.28-40

2004

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Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma : A tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis

Cancer research (Chicago, Ill.), 2005-03, Vol.65 (6), p.2474-2481

2005

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In vivo optical properties of cortical tubers in children with tuberous sclerosis complex (TSC): a preliminary investigation

Epilepsia (Copenhagen), 2011-09, Vol.52 (9), p.1699-1704

2011

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Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress

American journal of physiology. Renal physiology, 2012, Vol.72 (3)

2012

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Attention deficits in tuberous sclerosis complex (TSC): rethinking the pathways to the endstate

Journal of intellectual disability research, 2008-04, Vol.52 (4), p.348-357

2008

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Annual review of pharmacology and toxicology, 2012-01, Vol.52 (1), p.381-400

2012

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Critical roles for the TSC-mTOR pathway in β-cell function

American journal of physiology: endocrinology and metabolism, 2009, Vol.60 (5), p.1013-1022

2009

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Dysregulation of the TSC-mTOR pathway in human disease

Biallelic TSC gene inactivation in tuberous sclerosis complex

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

The long and winding road to rational treatment of cancer associated with LKB1 AMPK TSC mTORC1 signaling

Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway

Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity

Insulin signaling pathways in cortical dysplasia and TSC-tubers: Tissue microarray analysis

Clinical features distinguish childhood chordoma associated with tuberous sclerosis complex (TSC) from chordoma in the general paediatric population

Survey of Somatic Mutations in Tuberous Sclerosis Complex (TSC) Hamartomas Suggests Different Genetic Mechanisms for Pathogenesis of TSC Lesions

Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC‐cortical tubers

Focal cortical dysplasia: A genotype–phenotype analysis of polymorphisms and mutations in the TSC genes

Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: The role of promoter methylation of TSC genes

Graded loss of tuberin in an allelic series of brain models of TSC correlates with survival, and biochemical, histological and behavioral features

Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress

Neuropsychological attention deficits in tuberous sclerosis complex (TSC)

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology

Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma : A tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis

In vivo optical properties of cortical tubers in children with tuberous sclerosis complex (TSC): a preliminary investigation

Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress

Attention deficits in tuberous sclerosis complex (TSC): rethinking the pathways to the endstate

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

Critical roles for the TSC-mTOR pathway in β-cell function

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