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The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

Nature (London), 2011-01, Vol.469 (7329), p.241-244

2011

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Structure of a β1-adrenergic G-protein-coupled receptor

Nature (London), 2008-07, Vol.454 (7203), p.486-491

2008

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Case for continuing community NIV and CPAP during the COVID-19 epidemic

Thorax, 2020-05, Vol.75 (5), p.368-368

2020

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The signaling and selectivity of α‐adrenoceptor agonists for the human α2A, α2B and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

Pharmacology research & perspectives, 2022-10, Vol.10 (5), p.e01003-n/a

2022

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The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

Pharmacology research & perspectives, 2022-04, Vol.10 (2), p.e00936-n/a

2022

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The selectivity of β‐adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors

British journal of pharmacology, 2005-02, Vol.144 (3), p.317-322

Baker, Jillian G

2005

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A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors

PloS one, 2010-11, Vol.5 (11), p.e15487

2010

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The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors

Pharmacology research & perspectives, 2020-08, Vol.8 (4), p.e00602-n/a

2020

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The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors

Pharmacology research & perspectives, 2021-08, Vol.9 (4), p.e00799-n/a

2021

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β-Blockers, heart disease and COPD: current controversies and uncertainties

Thorax, 2017-03, Vol.72 (3), p.271-276

2017

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Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor

PloS one, 2013-11, Vol.8 (11), p.e77582-e77582

2013

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New Fluorescent Adenosine A1-Receptor Agonists That Allow Quantification of Ligand−Receptor Interactions in Microdomains of Single Living Cells

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.782-793

2007

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

Nature (London), 2011-01, Vol.469 (7329), p.241

2011

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Response to the letter Re: Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients

European journal of cancer (1990), 2021-07, Vol.152, p.252-254

2021

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Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Molecular pharmacology, 2019-12, Vol.96 (6), p.851-861

2019

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Rational design, synthesis, and pharmacological evaluation of a cohort of novel beta-adrenergic receptors ligands enables an assessment of structure-activity relationships

European journal of medicinal chemistry, 2023-01, Vol.246, p.114961-114961, Article 114961

2023

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Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11045-11053

2020

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The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β 1-Adrenoceptor

Molecular pharmacology, 2023-02, Vol.103 (2), p.89-99

2023

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Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling

Trends in pharmacological sciences (Regular ed.), 2011-04, Vol.32 (4), p.227-234

2011

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Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients

European journal of cancer (1990), 2021-04, Vol.147, p.106-116

2021

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Fragment evolution for GPCRs: the role of secondary binding sites in optimization

Chemical communications (Cambridge, England), 2021-10, Vol.57 (81), p.1516-1519

2021

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Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates

Trends in pharmacological sciences (Regular ed.), 2007-08, Vol.28 (8), p.374-381

2007

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Negative cooperativity across β1‐adrenoceptor homodimers provides insights into the nature of the secondary low‐affinity CGP 12177 β1‐adrenoceptor binding conformation

The FASEB journal, 2015-07, Vol.29 (7), p.2859-2871

2015

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Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H 1 , H 2 , and H 3 receptors

Chemical biology & drug design, 2019-01, Vol.93 (1), p.89

2019

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Influence of Agonist Efficacy and Receptor Phosphorylation on Antagonist Affinity Measurements: Differences between Second Messenger and Reporter Gene Responses

Molecular pharmacology, 2003-09, Vol.64 (3), p.679-688

2003

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The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

Structure of a β1-adrenergic G-protein-coupled receptor

Case for continuing community NIV and CPAP during the COVID-19 epidemic

The signaling and selectivity of α‐adrenoceptor agonists for the human α2A, α2B and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

The selectivity of β‐adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors

A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors

The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors

The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors

β-Blockers, heart disease and COPD: current controversies and uncertainties

Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor

New Fluorescent Adenosine A1-Receptor Agonists That Allow Quantification of Ligand−Receptor Interactions in Microdomains of Single Living Cells

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

Response to the letter Re: Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients

Comparative Docking to Distinct G Protein-Coupled Receptor Conformations Exclusively Yields Ligands with Agonist Efficacy

Rational design, synthesis, and pharmacological evaluation of a cohort of novel beta-adrenergic receptors ligands enables an assessment of structure-activity relationships

Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor

The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β 1-Adrenoceptor

Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling

Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients

Fragment evolution for GPCRs: the role of secondary binding sites in optimization

Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates

Negative cooperativity across β1‐adrenoceptor homodimers provides insights into the nature of the secondary low‐affinity CGP 12177 β1‐adrenoceptor binding conformation

Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H 1 , H 2 , and H 3 receptors

Influence of Agonist Efficacy and Receptor Phosphorylation on Antagonist Affinity Measurements: Differences between Second Messenger and Reporter Gene Responses

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