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Sex-Specific Multiparameter Blood Test for the Early Diagnosis of Alzheimer's Disease

International journal of molecular sciences, 2022-12, Vol.23 (24), p.15670

2022

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Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

Neurobiology of disease, 2005-10, Vol.20 (1), p.74-81

2005

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A conformation-specific antibody against oligomeric β-amyloid restores neuronal integrity in a mouse model of Alzheimer's disease

The Journal of biological chemistry, 2021-01, Vol.296, p.100241, Article 100241

2021

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Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Protein engineering, design and selection, 2010-06, Vol.23 (6), p.489-498

2010

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Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells

Neuroscience letters, 2009-07, Vol.459 (1), p.16-18

2009

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Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein

PloS one, 2013-02, Vol.8 (2), p.e55886

2013

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Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

The European journal of neuroscience, 2016-01, Vol.43 (1), p.3-16

2016

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Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

PloS one, 2009-05, Vol.4 (5), p.e5727-e5727

2009

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Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models

Biomolecules (Basel, Switzerland), 2015-07, Vol.5 (3), p.1634-1651

2015

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Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (15), p.e2025847118

2021

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Isolation and characterization of antibody fragment selective for human Alzheimer’s disease brain-derived tau variants

Neurobiology of aging, 2020-10, Vol.94, p.7-14

2020

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A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Neuropharmacology, 2015-10, Vol.97, p.457-463

2015

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Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP

Journal of molecular biology, 2011-01, Vol.405 (2), p.436-447

2011

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CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury

Neurology, 2018-10, Vol.91 (15), p.702

2018

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A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

Biotechnology progress, 2015-01, Vol.31 (1), p.289-298

2015

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Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

The Journal of biological chemistry, 2009-04, Vol.284 (17), p.11048-11058

2009

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CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

Integrative biology (Cambridge), 2011-12, Vol.3 (12), p.1188-1196

2011

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Isolation and characterization of antibody fragments selective for toxic oligomeric tau

Neurobiology of aging, 2015-03, Vol.36 (3), p.1342-1355

2015

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Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease

Journal of Alzheimer's disease, 2017-01, Vol.58 (1), p.23

2017

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Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity

Journal of molecular biology, 2007-05, Vol.368 (4), p.1132-1144

2007

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Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Neurobiology of aging, 2012-07, Vol.33 (7), p.1320-1328

2012

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Engineered Proteolytic Nanobodies Reduce Aβ Burden and Ameliorate Aβ-Induced Cytotoxicity

Biochemistry (Easton), 2010-06, Vol.49 (21), p.4501-4508

2010

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Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation

Journal of neuroscience research, 2004-01, Vol.75 (2), p.162-171

2004

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Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

Biotechnology progress, 2013-03, Vol.29 (2), p.463-471

2013

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A Human Single-Chain Fv Intrabody Blocks Aberrant Cellular Effects of Overexpressed α-Synuclein

Molecular therapy, 2004-12, Vol.10 (6), p.1023-1031

2004

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Sex-Specific Multiparameter Blood Test for the Early Diagnosis of Alzheimer's Disease

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

A conformation-specific antibody against oligomeric β-amyloid restores neuronal integrity in a mouse model of Alzheimer's disease

Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm

Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells

Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson's Disease Brains Are Differentially Generated in Mammalian Cell Models

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Isolation and characterization of antibody fragment selective for human Alzheimer’s disease brain-derived tau variants

A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity

Inhibiting β-Secretase Activity in Alzheimer's Disease Cell Models with Single-Chain Antibodies Specifically Targeting APP

CNS disease-related protein variants as blood-based biomarkers in traumatic brain injury

A Sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples

Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein

CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease

Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced Toxicity

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

Engineered Proteolytic Nanobodies Reduce Aβ Burden and Ameliorate Aβ-Induced Cytotoxicity

Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

A Human Single-Chain Fv Intrabody Blocks Aberrant Cellular Effects of Overexpressed α-Synuclein

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