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"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

Angewandte Chemie (International ed.), 1999-10, Vol.38 (19), p.2894-2896

1999

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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.137-142

2002

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Chimia, 2015-01, Vol.69 (7-8), p.407

2015

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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Nature (London), 1993-10, Vol.365 (6448), p.759-761

1993

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Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8534-8553

2020

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A Real-World Perspective on Molecular Design

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS medicinal chemistry letters, 2020-06, Vol.11 (6), p.1257-1268

2020

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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.5092-5097

2016

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A Real-World Perspective on Molecular Design: Miniperspective

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4087-4102

2016

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Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1599-1603

2005

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Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Heidelberg, Germany, March 15–18, 2009: Conference Report

Chimia, 2009-09, Vol.63 (9), p.573

2009

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Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2115-2127

2008

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Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design

Angewandte Chemie (International ed.), 2000-11, Vol.39 (22), p.4130-4133

2000

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Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Berlin, Germany, March 18–21, 2007: Conference Report

Chimia, 2007-09, Vol.61 (9), p.580

2007

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Channels and Transporters: Conference Report

Chimia, 2010-09, Vol.64 (9), p.662

2010

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The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

Chimia, 1996-11, Vol.50 (11), p.519

1996

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Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1110

1997

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Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010

Chimia, 2010, Vol.64 (9), p.662

2010

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Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3446-3449

2005

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Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist

Neuropharmacology, 2005-06, Vol.48 (7), p.1043-1055

2005

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Biosynthesis of porphyrins and related macrocycles. Part 53. Stereochemical studies on the enzymic formation of hydroxymethylbilane, the precursor of uroporphyrinogen III

Journal of the Chemical Society, Perkin Transactions 1, 1999 (19), p.2691-2698

1999

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Biosynthesis of porphyrins and related macrocycles. Part 52. Synthesis of (11-S )-[11-2H1]porphobilinogen and the (11R)-enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

Journal of the Chemical Society, Perkin Transactions 1, 1999 (19), p.2677-2689

1999

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Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

ChemMedChem, 2006-01, Vol.1 (1), p.45-48

2006

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Grundgerüstwechsel"︁ (Scaffold-Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

Angewandte Chemie, 1999-10, Vol.111 (19), p.3068-3070

1999

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Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (17), p.2223-2228

1997

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"Scaffold-Hopping" by Topological Pharmacophore Search: A Contribution to Virtual Screening

Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Stepwise Design of γ‑Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere

A Real-World Perspective on Molecular Design

Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors

A Real-World Perspective on Molecular Design: Miniperspective

Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design

Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Heidelberg, Germany, March 15–18, 2009: Conference Report

Benzodioxoles: Novel Cannabinoid-1 Receptor Inverse Agonists for the Treatment of Obesity

Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design

Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Berlin, Germany, March 18–21, 2007: Conference Report

Channels and Transporters: Conference Report

The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010

Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor

Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist

Biosynthesis of porphyrins and related macrocycles. Part 53. Stereochemical studies on the enzymic formation of hydroxymethylbilane, the precursor of uroporphyrinogen III

Biosynthesis of porphyrins and related macrocycles. Part 52. Synthesis of (11-S )-[11-2H1]porphobilinogen and the (11R)-enantiomer for stereochemical studies on hydroxymethylbilane synthase (porphobilinogen deaminase)

Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Grundgerüstwechsel"︁ (Scaffold-Hopping) durch topologische Pharmakophorsuche: ein Beitrag zum virtuellen Screening

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

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