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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Cell, 2020-10, Vol.183 (2), p.490-502.e18

2020

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Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Scientific reports, 2017-02, Vol.7 (1), p.42374-42374, Article 42374

2017

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Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

Journal of organic chemistry, 2018-01, Vol.83 (2), p.1077-1083

2018

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Cell reports (Cambridge), 2020-06, Vol.31 (12), p.107809, Article 107809

2020

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Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

Tetrahedron, 2008-04, Vol.64 (18), p.3885-3903

Shen, Hong C.

2008

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Design and Synthesis of Orally Bioavailable 4‑Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7651-7666

2016

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Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

Tetrahedron, 2008-08, Vol.64 (34), p.7847-7870

Shen, Hong C.

2008

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

ACS medicinal chemistry letters, 2014-09, Vol.5 (9), p.993-998

2014

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Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization

Organic & biomolecular chemistry, 2016-01, Vol.14 (18), p.4239-4246

2016

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Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors

European journal of medicinal chemistry, 2017-09, Vol.138, p.1147-1157

2017

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Asymmetric synthesis of chiral chromans

Tetrahedron, 2009-05, Vol.65 (20), p.3931-3952

Shen, Hong C.

2009

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Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic

Cells (Basel, Switzerland), 2022-11, Vol.11 (23), p.3868

2022

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.359-362

2015

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Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

ACS medicinal chemistry letters, 2016-08, Vol.7 (8), p.802-806

2016

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Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1789-1808

2012

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Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.558-562

2016

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Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Chemistry letters, 2017, Vol.46 (4), p.566-568

2017

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Synthesis of Chiral Chromans by the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA): Scope, Mechanism, and Applications

Journal of the American Chemical Society, 2004-09, Vol.126 (38), p.11966-11983

2004

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Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection

ACS infectious diseases, 2018-03, Vol.4 (3), p.257-277

2018

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Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Tetrahedron letters, 2016-02, Vol.57 (5), p.599-602

2016

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Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors

Bioorganic & medicinal chemistry letters, 2021-04, Vol.38, p.127862-127862, Article 127862

2021

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Highly Chemo- and Regioselective Vinylation of N‑Heteroarenes with Vinylsulfonium Salts

Journal of organic chemistry, 2018-08, Vol.83 (15), p.8627-8635

2018

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Syntheses of Seven-Membered Rings: Ruthenium-Catalyzed Intramolecular [5+2] Cycloadditions

Chemistry : a European journal, 2005-04, Vol.11 (8), p.2577-2590

2005

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Biomimetic Enantioselective Total Synthesis of (−)-Siccanin via the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA) and Sequential Radical Cyclizations

Journal of the American Chemical Society, 2004-10, Vol.126 (39), p.12565-12579

2004

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

Design and Synthesis of Orally Bioavailable 4‑Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction

Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization

Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors

Asymmetric synthesis of chiral chromans

Translation Potential and Challenges of In Vitro and Murine Models in Cancer Clinic

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors

Synthesis of Bridged Bicyclic Morpholine Amino Acids as Compact Modules for Medicinal Chemistry

Synthesis of Chiral Chromans by the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA): Scope, Mechanism, and Applications

Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection

Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery

Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors

Highly Chemo- and Regioselective Vinylation of N‑Heteroarenes with Vinylsulfonium Salts

Syntheses of Seven-Membered Rings: Ruthenium-Catalyzed Intramolecular [5+2] Cycloadditions

Biomimetic Enantioselective Total Synthesis of (−)-Siccanin via the Pd-Catalyzed Asymmetric Allylic Alkylation (AAA) and Sequential Radical Cyclizations

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